Bromophycoic Acids: Bioactive Natural Products from a Fijian Red Alga <i>Callophycus</i> sp.
Article 2012 en
Authors
MT
Margaret E. Teasdale
TS
Tonya L. Shearer
SE
Sebastian Engel
Abstract
1 min read
Bioassay-guided fractionation of extracts from a Fijian red alga in the genus Callophycus resulted in the isolation of five new compounds of the diterpene-benzoate class. Bromophycoic acids A-E (1-5) were characterized by NMR and mass spectroscopic analyses and represent two novel carbon skeletons, one with an unusual proposed biosynthesis. These compounds display a range of activities against human tumor cell lines, malarial parasites, and bacterial pathogens including low micromolar suppression of MRSA and VREF.
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