Red macroalgae are well-known for the production of brominated metabolites, including terpenoids and phenols, yet some taxa within the Rhodophyta remain relatively unstudied. Herein, we report the discovery of unusual diterpene-benzoate natural products representing three novel carbon skeletons, from the red alga Callophycus serratus collected in Fiji. Included among the new compounds were 15- and 16-membered macrolides as well as non-macrocyclic diterpene-benzoic acid structural motifs, all apparently sharing the same 27-carbon biosynthetic precursor. Biological activities of these compounds included moderate antibacterial, antiviral, and antineoplastic effects via specific apoptotic cell death.
Amy L. Lane, E. Paige Stout, Mark E Hay, Anne C. Prusak, Kenneth I. Hardcastle, Craig R. Fairchild, Scott G. Franzblau, Karine G. Le Roch, Jacques Prudhomme, William G.L. Aalbersberg, Julia Kubanek
Julia Kubanek, Anne C. Prusak, Terry W. Snell, Rachel Giese, Kenneth I. Hardcastle, Craig R. Fairchild, William G.L. Aalbersberg, Carmen Raventós-Suárez, Mark E Hay
Amy L. Lane, E. Paige Stout, An‐Shen Lin, Jacques Prudhomme, Karine G. Le Roch, Craig R. Fairchild, Scott G. Franzblau, Mark E Hay, William G.L. Aalbersberg, Julia Kubanek
An‐Shen Lin, E. Paige Stout, Jacques Prudhomme, Karine G. Le Roch, Craig R. Fairchild, Scott G. Franzblau, William G.L. Aalbersberg, Mark E Hay, Julia Kubanek
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