Antineoplastic Diterpene−Benzoate Macrolides from the Fijian Red Alga <i>Callophycus serratus</i>
Article 2005 en
Authors
JK
Julia Kubanek
AP
Anne C. Prusak
TS
Terry W. Snell
Abstract
1 min read
[structures: see text] Three diterpene-benzoate natural products, with novel carbon skeletons and an unusual proposed biosynthesis, were isolated from extracts of the Fijian red alga Callophycus serratus and identified by a combination of X-ray crystallographic, NMR, and mass spectral analyses. Bromophycolide A (1) displayed cytotoxicity against several human tumor cell lines via specific apoptotic cell death. This represents the first discovery of natural products incorporating a diterpene and benzoate skeleton into a macrolide system.
Amy L. Lane, Anne C. Prusak, Mark E Hay, Terry W. Snell, R.A. Giese, Kenneth I. Hardcastle, C.R. Fairchild, William G.L. Aalbersberg, Carmen Raventós-Suárez, Julia Kubanek
Amy L. Lane, E. Paige Stout, Mark E Hay, Anne C. Prusak, Kenneth I. Hardcastle, Craig R. Fairchild, Scott G. Franzblau, Karine G. Le Roch, Jacques Prudhomme, William G.L. Aalbersberg, Julia Kubanek
An‐Shen Lin, E. Paige Stout, Jacques Prudhomme, Karine G. Le Roch, Craig R. Fairchild, Scott G. Franzblau, William G.L. Aalbersberg, Mark E Hay, Julia Kubanek
Amy L. Lane, E. Paige Stout, An‐Shen Lin, Jacques Prudhomme, Karine G. Le Roch, Craig R. Fairchild, Scott G. Franzblau, Mark E Hay, William G.L. Aalbersberg, Julia Kubanek
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