Publications

Starting from commercially available (rac)-3-cyclohexene-1-carboxylic acid, a series of purine and pyrimidine cis-substituted cyclohexenyl and cyclohexanyl nucleosides were synthesized through a key Mitsunobu reaction. Antiviral evaluations were performed on HIV, coxsackie B3, and herpes viruses (HSV-1, HSV-2, VZV, HCMV). Three compounds showed moderate activity against HSV-1 and coxsackie viruses. Specific computer modeling studies were performed on HSV-1 thymidine kinase in order to understand the enzyme activation of an analogue showing moderate antiviral activity.

Laser powder bed fusion (L-PBF) is one of the most promising additive manufacturing (AM) methods which provides an exceptional opportunity to improve the existing designs and move toward fabricating fine features and complex geometries with higher efficiencies. Considering the layer-wise nature of this technique, the possibility of fabricating fine features is tied to the ability to deposit thin powder layers in this process. Since the powder layer thickness is directly dictated by the powder particle size, finer powders are required to further enhance the ability of the L-PBF technique in manufacturing fine features and intricate geometries. Accordingly, this study aims at investigating the processability of fine AlSi10Mg powder (D50 = 9 µm) by using the L-PBF process. The densification level, surface quality and dimensional accuracy of the final parts are investigated in a wide range of process parameters and are compared to those manufactured by the commonly used AlSi10Mg powder (referred to as coarse powder with D50 = 40 µm). The underlying reasons behind the different processability of fine and coarse powders are explored from the density, surface quality, microhardness and dimensional accuracy viewpoints through analyzing the flowability, bed packing density and optical absorption of powders. Moreover, the process-microstructure-microhardness relationship is assessed in detail for both fine and coarse powders. This study reinforces the idea that the utilization of fine powders in the range used in this study for L-PBF processing is rather challenging.

New mononuclear Ru(II) complexes [Ru(A)2(B)]2+, where A = 2,2′-bipyridine/1,10-phenanthroline and B = 3,4,5-tri-OCH3-DPC, 4-CH3-DPC, 4-N(CH3)2-DPC, 4-NO2-DPC, N-BITSZ, PTSZ and PINH, were prepared and characterized by spectroscopic methods. The in vitro cytotoxic activities of the complexes and their corresponding ligands were investigated against the human cancer T-lymphocyte cell lines molt 4/c8 and CEM and the murine tumor leukemia cell line L1210, human promyelocytic leukemia cells (HL-60) and Bel-7402 liver cancer cells by MTT assay. The complexes [Ru(A)2(B)]2+ (A = 1,10-phenanthroline, B = 3,4,5-tri-OCH3-DPC) exerts rather more potent activities against all of these cell lines, especially for CEM and L1210. Ru complexes and structure–activity relationships and anticancer mechanisms are also discussed.

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.