Synthesis and QSAR Studies on Thiazolidinones as Anti-HIV Agents

Ravindra K. Rawal; V. Raja Solomon; Yenamandra S. Prabhakar; S. B. Katti; De Clercq Erik

doi:10.2174/1386207054546496

Abstract

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Selected 4-thiazolidinone have been synthesized and tested as anti-HIV activity. The results of the in vitro tests showed that one of the compounds, 5, inhibited the enzyme at 0.204 microM concentration with minimal toxicity to MT-4 cell. Furthermore, the QSAR studies indicated the role of PMIZ, Ovality and Total energy content of the compounds in rationalizing the activity.

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