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Purpose This paper aims to present a possible complete set of dimensionless parameters to describe the process of selective laser melting (SLM). This makes it possible to compare the similarity between different experiments, a sine‐qua‐non for a correct comparison of the results. Design/methodology/approach The paper describes the application of dimensional analysis to SLM. Findings Although the idea of dimensionless numbers is far from new, it has apparently never been applied rigorously to rapid prototyping and rapid manufacturing technologies. The technique is important, since it reduces the number of factors and makes it possible to compare results of different research groups. Furthermore, some more fundamental insights about the process can be gained. Originality/value This work is a first step towards a manageable system to control very difficult processes.
No abstract is provided for this article.
Inhibition of HIV-1 replication by differently substituted spirocyclopropyl compounds has been evaluated. Compound 21 showed a moderate activity (EC50 ranging from 2.3 to 5.8 micrograms/ml) against different HIV-1 strains (IIIB, RF, NDK, and an AZT-resistant strain) in different cell lines (MT-4 and C-8166 cells), while it was cytotoxic at 77.7 micrograms/ml, resulting in a selectivity index of 34. This compound was inactive against HIV-2 (ROD) and SIV (MAC251). From "time-of-addition" experiments compound 21, like AZT, appeared to inhibit HIV-1 at the reverse transcriptase step.
This paper describes the development of an “extended CAM system” for multi-axes milling, integrating tool path generation, axes transformation (postprocessing) and NC-simulation. The system performs an immediate verification of each generated cutter location and in case a collision occurs (e.g. between machine and part), it takes the appropriate action by applying a collision avoidance algorithm. Different collision avoidance algorithms have been implemented: change of tool orientation, selection of other machine axes configurations and simple tool retract. The effect of a tool orientation change on the quality of the machined surface has been studied in order to define the range of tool orientations that may be used for collision avoidance.
Depending on the stage of their intervention with the viral replicative cycle, human immunodeficiency virus inhibitors could be divided into the following groups: (i) adsorption inhibitors (i.e., CD4 constructs, polysulfates, polysulfonates, polycarboxylates, and polyoxometalates), (ii) fusion inhibitors (i.e., plant lectins, succinylated or aconitylated albumins, and betulinic acid derivatives), (iii) uncoating inhibitors (i.e., bicyclams), (iv) reverse transcription inhibitors acting either competitively with the substrate binding site (i.e., dideoxynucleoside analogs and acyclic nucleoside phosphonates) or allosterically with a nonsubstrate binding site (i.e., non-nucleoside reverse transcriptase inhibitors), (v) integration inhibitors, (vi) DNA replication inhibitors, (vii) transcription inhibitors (i.e., antisense oligodeoxynucleotides and Tat antagonists), (viii) translation inhibitors (i.e., antisense oligodeoxynucleotides and ribozymes), (ix) maturation inhibitors (i.e., protease inhibitors, myristoylation inhibitors, and glycosylation inhibitors), and finally, (x) budding (assembly/release) inhibitors. Current knowledge, including the therapeutic potential, of these various inhibitors is discussed. In view of their potential clinical the utility, the problem of virus-drug resistance and possible strategies to circumvent this problem are also addressed.
