ChemInform Abstract: Synthesis of 5‐(1‐Substituted Ethyl)uracil Derivatives and Some of Their Chemical and Biological Properties.

A. S. JONES; Michael J. McClean; Matthew James Slater; Richard Walker; Jan Balzarini; De Clercq Erik

doi:10.1002/chin.198724321

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ChemInform Abstract: Synthesis of 5‐(1‐Substituted Ethyl)uracil Derivatives and Some of Their Chemical and Biological Properties.

Article 1987 en

Abstract

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Abstract Reaction of the deoxyuridine (I) with thiophenol (II) under radical conditions gives the 2‐phenylthioethyl deoxyuridine (IIIa), which can be oxidized to the sulfone (IIIb) (MCPBA, 42% yield) or the sulfoxide (IIIc) (NaIO 4 , 91%).

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