Novel Series of [ddN]-[TSAO-T] Heterodimers as Potential Bi-Functional Inhibitors of HIV-1 RT. Studies in the Linker and ddN Region — Sonsoles Velázquez (1999) | RDL Network
Novel Series of [ddN]-[TSAO-T] Heterodimers as Potential Bi-Functional Inhibitors of HIV-1 RT. Studies in the Linker and ddN Region
Article 1999 en
Authors
SV
Sonsoles Velázquez
VT
V. Tuñón
MJ
M. Luísa Jimeno
Abstract
1 min read
Novel series of [ddN]-(CH2)n-[TSAO-T] heterodimers have been prepared and tested for their anti-HIV-1 and HIV-2 activity. The most active compound of this series was the [d4T]-(CH2)3-[TSAO-T] heterodimer (EC50 = 0.018 +/- 0.03 microM).
Sonsoles Velázquez, Cristina Chamorro, María‐Jesús Pérez‐Pérez, Rosa Álvarez, M. Luísa Jimeno, Nazario Martı́n, Carlos A. Perez, Federico Gago, De Clercq Erik, Jan Balzarini, Ana San‐Félix, Marı́a-José Camarasa
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