288 publications from this institution
In this study, 13 tumor cell line derived subcutaneous models and one intracranial tumor model were evaluated by the application of X-ray radiation. The response of radiation levels on different tumor types and different tumor models were assessed by using the device (X-RAD225, Pxi precision, USA) delivering the targeted radiation directly on the focal tumor site. Furthermore, we investigated the combined benefits of radiation and a chemotherapy medication, Gemcitabine, on the H22 murine hepatic carcinoma cells derived subcutaneous syngeneic model. The impact of radiation treatment on the NCI-H1975-luc, human non-small cell lung cancer intracranial model in combination with Human checkpoint kinase ataxia telangiectasia-mutated (ATM) kinase inhibitor AZD0156 was studied. In addition, the integrity of the blood-brain barrier and the presence of the pharmacodynamic marker pRAD50 of AZD0156 were evaluated. The study outcome demonstrated that X-ray radiation has anti-tumor effects across all studied models, and also in combination treatment with radiosensitizer, Gemcitabine or AZD0156. We believe this study demonstrates there is a lot of potential fully utilizing radiation platform identifying radiation sensitizer or chemo candidates to benefit the management of oncology society.
Flame spread over wire surface is different from other solid fires as it is usually accompanied by melting and dripping processes. Although the related behaviors at reduced pressure (20–100 kPa) are significant to those fire risk evaluations, very few studies have been undertaken on this matter. Therefore, the thermoplastic dripping and flame spread behaviors of energized polyethylene insulated copper wires were investigated experimentally at reduced pressure. It was known from experimental results that the dripping frequency increases, showing a relatively smooth (linear) and rapid (power) increasing trends under high and low electrical currents, respectively. A short-period flame disappearance was observed during the dripping process, which is unique for the energized wire at reduced pressure. The bright flame can disappear for several seconds and then show again after the dripping. While at 20 kPa or lower, the wire flame would turn to a completed extinguishment after the dripping. A critical dripping point was proposed to show the minimal required electrical current to sustain the flame spearing. The critical current changes smoothly during 100–80 kPa and decreases rapidly at 80–60 kPa. Additionally, the dripping phenomenon can stop or delay the flame spread, partly because of the short-term flame disappearance.
