10,000 publications from this institution
<p>Western blotting analysis of COMMED1, Skp2, p21, and α-Clusterin protein expression in vehicle control and DSF/CuCl2 treated 22Rv1-DR xenograft tumors.</p>
The performance of the code generated by a compiler depends on the order in which the optimization passes are applied. In high-level synthesis, the quality of the generated circuit relates directly to the code generated by the front-end compiler. Choosing a good order-often referred to as the phase-ordering problem-is an NP-hard problem. In this paper, we evaluate a new technique to address the phase-ordering problem: deep reinforcement learning. We implement a framework in the context of the LLVM compiler to optimize the ordering for HLS programs and compare the performance of deep reinforcement learning to state-of-the-art algorithms that address the phase-ordering problem. Overall, our framework runs one to two orders of magnitude faster than these algorithms, and achieves a 16% improvement in circuit performance over the -O3 compiler flag.
We have placed the genes encoding ribulose-bisphosphate carboxylase/oxygenase from the Anabaena 7120 operon under transcriptional control of the lac promoter carried on the Escherichia coli plasmid pUC19. The genes encoding both the large and small subunit polypeptides ( rbcL and rbcS ) are transcribed and translated so that ≈0.6% of the soluble protein in E. coli extracts is a fully functional holoenzyme with a sedimentation coefficient of approximately 18S, which contains stoichiometric amounts of the two subunits. However, expression of the large subunit polypeptide vastly exceeds that of the small subunit because the majority of transcripts terminate in the intergenic region between the rbcL and rbcS genes. As a result, excess large subunit is synthesized and accumulates in E. coli as an insoluble and catalytically inactive form. Because small subunit is found only in the high molecular weight soluble form of ribulosebisphosphate carboxylase/oxygenase, we propose that the small subunit promotes assembly of the hexadecameric form of the enzyme via heterodimers of large and small subunits.
Abstract The electron‐rich title complex (II) is formed by a process typical of other low‐valent late transition‐metal complexes but its reactions are either unprecedented or similar to those seen with electrophilic d0 benzyne complexes (see scheme).
Reducing high public debts is key for countries seeking to restore fiscal capacity and resilience in the wake of recent crises.But large debt reductions are rare.Jamaica stands out for reducing its debt from 144 percent of GDP to 72 percent over the last decade, a record achieved by running large, persistent primary budget surpluses.Well-designed fiscal rules combined with social partnership agreements making for fiscal ownership are at the root of its achievement.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
