Purpose – To discuss synthesis and evaluation of organo‐metallic chalcones as second‐order nonlinear optical (SONLO) materials.
Background: In coronary lesions characterized by bifurcation anatomies, provisional side‐branch intervention is the preferred treatment approach. However, there is a well‐documented discrepancy between angiographic evaluations of blood flow obstruction and the actual functional severity of bifurcation lesions. Additionally, the use of fractional flow reserve (FFR) carries notable side effects primarily associated with the necessity of adenosine administration. Given the demonstrated noninferiority of the instantaneous wave‐free ratio (iFR) compared to FFR, this study aimed to assess the clinical and functional benefits of iFR‐guided side‐branch ballooning which involving drug‐eluting balloon inflation in side branch in comparison to conventional intervention techniques for bifurcation lesions. Methods: In this prospective cohort study, a total of 100 patients with coronary lesions characterized by bifurcation anatomies were enrolled and randomly assigned to two groups: the iFR‐based intervention group, which utilized only side‐branch intervention involving drug‐eluting balloon inflation, and the conventional intervention group. Both groups were monitored for 12 months postintervention to assess various clinical and functional endpoints. Results: In the iFR‐guided group, only 2 patients (4%) met the primary endpoint (a composite of target bifurcation‐related nonfatal myocardial infarction, target bifurcation revascularization, and any unplanned revascularization) compared to 10 patients (20%) in the conventional group ( p = 0.01). The study also demonstrated the superiority of iFR‐guided drug‐eluting balloon inflation in side branches over conventional interventional procedures for bifurcation lesions, as evidenced by a reduction in fluoroscopy time (mean difference [MD] = −8.9 min, 95% confidence interval [CI] = −15.6 to −2.1, p = 0.01), intervention duration (MD = −11.6 min, 95% CI = −20.5 to −2.8, p = 0.01), and length of hospital stay (MD = −1 day, 95% CI = −1.2 to −0.80, p < 0.0001). Additionally, the amount of contrast media used in the iFR‐guided intervention group was significantly lower than that in the conventional treatment group ( p < 0.0001). Conclusions: iFR‐guided side‐branch intervention involving drug‐eluting balloon inflation in bifurcation lesions was significantly better when compared to conventional interventions in terms of clinical and functional outcomes in patients with coronary lesions characterized by bifurcation anatomies.
This Concept is aimed at describing the current state of the art in metal-organic frameworks (MOFs) as heterogeneous catalysts for liquid-phase oxidations, focusing on three important substrates, namely, alkenes, alkanes and alcohols. Emphases are on the nature of active sites that have been incorporated within MOFs and on future targets to be set in this area. Thus, selective alkene epoxidation with peroxides or oxygen catalyzed by constitutional metal nodes of MOFs as active sites are still to be developed. Moreover, no noble metal-free MOF has been reported to date that can act as a general catalyst for the aerobic oxidation of primary and secondary aliphatic alcohols. In contrast, in the case of alkanes, a target should be to tune the polarity of MOF internal pores to control the outcome of the autooxidation process, resulting in the selective formation of alcohol/ketone mixtures at high conversion.
A bis-chalcone has been synthesized by reaction of 3-acetyl-,5-dimethylthiophene and terephthalaldehyde in ethanolic NaOH at room temperature: (2E,2'E)-3,3-(1,4-phenylene)bis[1-(2,5-dimethyl-3-thienyl)prop-2-en-1-one] (3) was obtained in high yield. The structure of this compound was established by elemental analysis, IR, 1H NMR, 13C NMR and EI-MS spectral analysis.
Cobalt pyrite-decorated carbon nanotube nanocomposites (CoS<sub>2</sub>–CNT NCs) were prepared by a simple wet-chemical method and applied for a selective and sensitive hydrazine sensor.
Using one-step wet-chemically synthesized ternary ZnO/CuO/Co<sub>3</sub>O<sub>4</sub>nanoparticles (NPs) fabricated GCE sensor probe, a selective and sensitive melamine chemical sensor was developed by electrochemical approach, which exhibited the highest sensitivity, better repeatability, broad linear dynamic range, good linearity, fast response time, and lowest detection limit.
Here, the voltammetric electrochemical approach was applied to detect uric acid (UA) in a conductive sensing medium (phosphate buffer solution-PBS) by using PbO-doped NiO nanocomposites (NCs)-decorated glassy carbon electrode (GCE) performing as working electrode. The wet-chemically prepared PbO-doped NiO NCs were subjected to characterization by the implementation of XRD, FESEM, XPS, and EDS analysis. The modified GCE was used to detect uric acid (UA) in an enzyme-free conductive buffer (PBS) of pH = 7.0. As the outcomes of this study reveal, it exhibited good sensitivity of 0.2315 µAµM<sup>-1</sup>cm<sup>-2</sup> and 0.2233 µAµM<sup>-1</sup>cm<sup>-2</sup>, corresponding to cyclic (CV) and differential pulse (DPV) voltammetric analysis of UA, respectively. Furthermore, the proposed UA sensor showed a wider detection (0.15~1.35 mM) range in both electrochemical analysis methods (CV & DPV). In addition, the investigated UA sensor displayed appreciable limit of detection (LOD) of 41.0 ± 2.05 µM by CV and 43.0 ± 2.14 µM by DPV. Good reproducibility performance, faster response time and long-time stability in detection of UA were perceived in both electrochemical analysis methods. Finally, successful analysis of the bio-samples was performed using the recovery method, and the results were found to be quite acceptable in terms of accuracy. Thus, the findings indicate a reliable approach for the development of 5th generation biosensors using metal-oxides as sensing substrate to fulfill the requirements of portable use for in situ detection.
