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An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Several salt forms of 4-aminopyridine and 3,4-diaminopyridine with nitric, sulfuric, and phosphoric acids, comprising anhydrates and some hydrates, have been prepared and structurally characterized, and the role of water assessed in the latter cases. Our study has confirmed that anhydrates can be obtained even when water is present in the crystallizing solution. Protonation of the aminopyridines is consistent with ΔpKa differences. 4-Aminopyridine uniquely forms a mono cation only, with protonation at the pyridine nitrogen, whilst 3,4-diaminopyridine forms both a mono cation, again with protonation at the pyridine nitrogen, and a dication, with the second protonation at the 3-amino position. Thus, 4-aminopyridine forms a 1 : 1 nitrate anhydrate, a 1 : 1 bisulphate anhydrate, a 2 : 1 sulfate hydrate and a 1 : 1 dihydrogen phosphate hydrate. 3,4-Diaminopyridine forms a 1 : 1 nitrate anhydrate and 1 : 2 nitrate anhydrate and hydrate, 2 : 1 and 1 : 1 sulfate hydrates and a 1 : 1 dihydrogen phosphate anhydrate. Analysis of the structures found suggests that the H-bonding capability of the water O–H donors and O acceptor components have similar tendencies to N–H donors and other O acceptors. At the same time, we recognise that, whilst water molecules may occasionally be structure forming, they also act as spacers or fillers in the development of the primary H-bonded assemblies. These will mainly be controlled by the stoichiometries and H-bonding possibilities of the anion/cation components. It is also possible that, in some circumstances, the inclusion or otherwise of water in structures may be competitive with supplementary weak interactions such as C–H⋯O hydrogen bonding.

ABSTRACT A new series of polyarylidene(keto amine)s (PAKAs) 3 a −3 e based on thiophene moieties in polymer main chains were synthesized with the solution polycondensation technique. The polymers were synthesized by the reaction of the new monomer 1,1′‐(1 E ,1′ E )‐(2‐oxocyclohexane‐1,3‐diylidene)bis(methanylylidene)bis(thiophene‐5,2‐diyl)bis(2‐chloroethanone) ( 2 ) with different diamines. The new monomer was first synthesized under the normal conditions of the Friedel–Crafts reaction. The results obtained from both elemental and spectral analyses were consistent with the chemical structure of the new monomers and the polymers. Moreover, the identification of the polymers was carried out with different characterization techniques. The analytical competition of the newly synthesized PAKA polymers as selected examples ( 3 d and 3 e ) was also evaluated for a selective extraction of metal ions, including Cd(II), Co(II), Cu(II), Cr(III), Fe(III), Ni(II), and Zn(II), before their determination by inductively coupled plasma–optical emission spectrometry. The results of the selectivity study demonstrated that the 3 d and 3 e polymers was the most selective toward Co(II) and Fe(III), respectively. However, the adsorption capacity of 3 d for Co(II) was improved by 10.10% in comparison to that of 3 e for Fe(III) after only 1 h of contact time. Moreover, the adsorption isotherm data also showed that the adsorption process was mainly monolayer on the homogeneous adsorbent surfaces of both polymers. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40873.

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Correction for ‘Cation optimization for <italic>burn-in loss-free</italic> perovskite solar devices’ by Sanghyun Paek <italic>et al.</italic>, <italic>J. Mater. Chem. A</italic>, 2021, <bold>9</bold>, 5374–5380, DOI: 10.1039/D1TA00472G.

Objective: The current systematic review was carried out to compare the safety and efficacy of thalidomide vs hydroxyurea in β-thalassemia patients. Methods: literature were extensively searched by using four databases: Web of Science, PubMed, Cochrane Library, and Scopus until January 22, 2024, for studies that did hit to hit comparison of thalidomide vs hydroxyurea based on safety and efficacy in β-thalassemia patients. Original research studies in English with observational and/or experimental designs, regardless of age and gender, used thalidomide for ≥3 months were included in this systematic review. Two independent reviewers extracted the data using a data extraction form. Results: Two studies collectively involving n=57 β-thalassemia patients fulfilled eligibility criteria. Thalidomide exhibited greater potential in improving Hb levels, HbF, and in reducing blood transfusion needs and serum ferritin levels compared to hydroxyurea in β-thalassemia patients. Mild adverse events (AEs) of non-serious nature were reported with both thalidomide and hydroxyurea. somnolence, and headache were the main AEs reported in patients treated with thalidomide, whereas abdominal pain, pruritis and gastritis were the main AEs reported in patients treated with hydroxyurea. Conclusion: This study demonstrates the higher potential of thalidomide in improving Hb levels and reducing transfusion requirements compared to hydroxyurea in β-thalassemia. However, these findings must be endorsed until well-designed clinical trials are conducted.