Synthesis, Solution Conformation and Biological properties of 2',3'-Dideoxy-3'-fluoro-D-erythro-pentofuranosides of 2-Thiouracil and 2-Thiothymine — Nicolai E. Poopeiko (1995) | RDL Network
Synthesis, Solution Conformation and Biological properties of 2',3'-Dideoxy-3'-fluoro-D-erythro-pentofuranosides of 2-Thiouracil and 2-Thiothymine
Article 1995 en
Authors
NP
Nicolai E. Poopeiko
JP
Jarosław Poznański
AD
Alicja K. Drabikowska
Abstract
1 min read
Abstract The synthesis of the α- and β-anomers of 2′,3′-dideoxy-3′-fluoro-2-thiouridine and 2′,3′-dideoxy-3′-fluoro-2-thiothymidine via Lewis acid catalysed nucleoside condensation is described. High resolution 1H NMR data, solution conformations and biological properties are also presented.
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