Synthesis and Biological Evaluation of a Series of Substituted Pyridine-C-Nucleosides. Part V: 3-Chloro-4-(D-Ribofuranosyl)Pyridine and 3-(D-Ribofuranosyl)-2-Pyridone

Abstract The total synthesis of 3-chloro-4-(D-ribofuranosyl)-pyridine and 3-(D-ribo-furanosyl)-2-pyridone was elaborated using the appropriate lithiopyridines and 2,4:3,5-di-O-benzylidene-aldehydo-D-ribose. The conformation of these compounds was investigated by 360 MHz 1H-NMR. The compounds were evaluated as α,β-mixtures for their antiviral and cytostatic properties. However, no significant biological activity was found.