Heteroarylether 1,3-diarylureas in the thieno[3,2-d]pyrimidine series as VEGFR2 tyrosine kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays

Maria João R.P. Queiroz; Daniela Peixoto; Pedro Soares; Rui M.V. Abreu; Hugo J.C. Froufe; Ricardo C. Calhelha; Isabel Cristina Fernandes Rodrigues Ferreira; Raquel Costa; Raquel Soares

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Isabel Cristina Fernandes Rodrigues Ferreira

Heteroarylether 1,3-diarylureas in the thieno[3,2-d]pyrimidine series as VEGFR2 tyrosine kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays

Article 2013 en

Authors

MQ
Maria João R.P. Queiroz
DP
Daniela Peixoto
PS
Pedro Soares

Abstract

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Foundation for the Science and Technology (FCT–Portugal) for financial support through the PTNMR network (Bruker 400 Avance III-Univ Minho). FCT and FEDER-COMPETE/QREN/EU for financial support through the research unities PEst-C/QUI/UI0686/2011, PEst-OE/AGR/UI0690/2011, PEst-OE/SAU/UI0038/2011, the research project PTDC/QUI- QUI/111060/2009 and the post-Doctoral grant attributed to R.C.C. (SFRH/BPD/68344/2010).

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Heteroarylether 1,3-diarylureas in the thieno[3,2-d]pyrimidine series as VEGFR2 tyrosine kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays

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