1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays

Daniela Peixoto; Ricardo C. Calhelha; Pedro Soares; Rui M.V. Abreu; Hugo J.C. Froufe; Isabel Cristina Fernandes Rodrigues Ferreira; Raquel Costa; Raquel Soares

Abstract

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Acknowledgments:To the FCT–Portugal for financial support through the PTNMR network. To FCT and COMPETE/QREN/EU for financial support through the research unities PEst-C/QUI/UI686/2011, PEst-OE/AGR/UI0690/2011, PEst-OE/SAU/UI0038/2011, the research project PTDC/QUI-QUI/111060/2009 and the post-Doctoral grant attributed to R.C.C. (SFRH/BPD/68344/2010) also financed by POPH and FSE.

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1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays

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