Distinctive molecular inhibition mechanisms for selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1

Hua Tu; Jay P. Powers; Jinsong Liu; Stefania Ursu; Athena Sudom; Xuelei Yan; Haoda Xu; David Meininger; Michael DeGraffenreid; Xiaodong He; Juan C. Jaén; Daqing Sun; Marc Labelle; Hiroshi Yamamoto; Bei Shan; Nigel P.C. Walker; Zhong Lin Wang

doi:10.1016/j.bmc.2008.08.065

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Distinctive molecular inhibition mechanisms for selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1

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The selectivity of tyrosine 280 of human 11β‐hydroxysteroid dehydrogenase type 1 in inhibitor binding