Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4

Jay P. Powers; Shyun Li; Juan C. Jaén; Jinqian Liu; Nigel P.C. Walker; Zhong Lin Wang; Holger Wesche

doi:10.1016/j.bmcl.2006.03.020

Related publications

Article2015

Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4

Zhong Lin Wang, Daqing Sun, Sheree Johnstone, Zhaodan Cao, Xiong Gao, Juan C. Jaén, Jingqian Liu, Sarah Lively, Shichang Miao, Athena Sudom, Craig S. Tomooka, Nigel P.C. Walker, Matthew Wright, Xuelei Yan, Qiuping Ye, Jay P. Powers

Article2008

Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1)

Daqing Sun, Zhong Lin Wang, Yongmei Di, Juan C. Jaén, Marc Labelle, Ji Ma, Shichang Miao, Athena Sudom, Liang Tang, Craig S. Tomooka, Hua Tu, Stefania Ursu, Nigel P.C. Walker, Xuelei Yan, Qiuping Ye, Jay P. Powers

Article2007

FADD Negatively Regulates Lipopolysaccharide Signaling by Impairing Interleukin-1 Receptor-Associated Kinase 1-MyD88 Interaction

Rachel Zhande, Shauna Dauphinee, James A. Thomas, Masahiro Yamamoto, Akira Shizuo, Aly Karsan

Molecular and Cellular Biology

Article2010

Discovery of Novel Fibroblast Growth Factor Receptor 1 Kinase Inhibitors by Structure-Based Virtual Screening

Krishna Pratap Ravindranathan, Valsan Mandiyan, Anil R. Ekkati, Jae Hyun Bae, Joseph Schlessinger, William L. Jorgensen

Journal of Medicinal Chemistry

Article2005

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction

Satoshi Uematsu, Shintaro Sato, Masahiro Yamamoto, Tomonori Hirotani, Hiroki Kato, Fumihiko Takeshita, Michiyuki Matsuda, Cevayir Coban, Ken J. Ishii, Taro Kawai, Osamu Takeuchi, Akira Shizuo

The Journal of Experimental Medicine