Antibacterial Neurymenolides from the Fijian Red Alga <i>Neurymenia fraxinifolia</i>
Article 2008 en
Authors
ES
E. Paige Stout
AH
Adam P. Hasemeyer
AL
Amy L. Lane
Abstract
1 min read
Two novel alpha-pyrone macrolides, neurymenolides A (1) and B (2), were isolated from the Fijian red alga Neurymenia fraxinifolia and characterized using a combination of NMR and mass spectral analyses. These molecules represent only the second example of alpha-pyrone macrolides, with 1 existing as interchanging atropisomers due to restricted rotation about the alpha-pyrone ring system. Neurymenolide A (1) displayed moderately potent activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF).
E. Paige Stout, Adam P. Hasemeyer, Amy L. Lane, Theresa M. Davenport, Sebastian Engel, Mark E Hay, Craig R. Fairchild, Jacques Prudhomme, Karine G. Le Roch, William G.L. Aalbersberg, Julia Kubanek
Margaret E. Teasdale, Tonya L. Shearer, Sebastian Engel, Troy S. Alexander, Craig R. Fairchild, Jacques Prudhomme, Manuel Torres, Karine G. Le Roch, William G.L. Aalbersberg, Mark E Hay, Julia Kubanek
Amy L. Lane, E. Paige Stout, An‐Shen Lin, Jacques Prudhomme, Karine G. Le Roch, Craig R. Fairchild, Scott G. Franzblau, Mark E Hay, William G.L. Aalbersberg, Julia Kubanek
Amy L. Lane, E. Paige Stout, Mark E Hay, Anne C. Prusak, Kenneth I. Hardcastle, Craig R. Fairchild, Scott G. Franzblau, Karine G. Le Roch, Jacques Prudhomme, William G.L. Aalbersberg, Julia Kubanek
An‐Shen Lin, E. Paige Stout, Jacques Prudhomme, Karine G. Le Roch, Craig R. Fairchild, Scott G. Franzblau, William G.L. Aalbersberg, Mark E Hay, Julia Kubanek
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