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The present invention relates to compositions and methods for cancer diagnosis, treatment and drug screening. In particular, the present invention provides compositions and methods for targeting the nuclear translocation of IkB kinase-.alpha. (IKK.alpha.) and the IKK.alpha.-mediated suppression of Maspin expression observed in metastatic prostate cancer cells.
Objectives This study was designed to assess patterns of objectively measured physical activity (PA) and sedentary behaviour in a sample of adults in a rural setting from a low-income Sub-Saharan African country (Malawi). The patterns of PA and sedentary behaviour in Malawi were compared with US data collected and analysed using the same methodology. Methods The Malawi PA data were collected as part of a survey experiment on the measurement of agricultural labor conducted under the World Bank Living Standards Measurement Study program. ActiGraph accelerometers (model GT3X) were worn on the right hip in a household-based sample of 414 working-age adults (15–85 years). Results Mean total and 95% CIs for PA by category in min/day for Malawi adults were: sedentary 387.6 (377.4–397.8), low-light 222.1 (214.7–229.5), high-light 136.3 (132.7–139.9), moderate 71.6 (68.8–74.5), vigorous 1.1 (0.5–1.8) and moderate-to-vigorous physical activity (MVPA) 72.8 (69.7–75.9). Mean of PA and sedentary behavior (min/day) summed across age and sex groups are compared between Malawi and US samples: sedentary behaviour, 387.6 vs 525.8 (p<0.001); low-light, 222.1 vs 217.0 (p=ns); high-light, 136.3 vs 45.6 (p<0.001); moderate, 71.6 vs 28.0 (p<0.001); vigorous, 1.1 vs 2.5 (p<0.001); MVPA, 72.8 vs 30.5 (p<0.001). Compared with the USA, Malawi participants averaged consistently less sedentary time/day and more minutes/day in all intensity levels of PA, except for low-light and vigorous PA. Conclusion Overall, levels of MVPA and high-light activity in adults in Malawi were substantially higher and sedentary time was substantially lower than those observed in US samples using near identical data collection, scoring and analysis.
(2004). Coeducational and Single-Sex Physical Education in Middle Schools: Impact on Physical Activity. Research Quarterly for Exercise and Sport: Vol. 75, No. 4, pp. 446-449.
Background Neighbourhood walkability is known to be positively associated with self-reported and device-based measures of overall physical activity. However, relations of walkability with specific active and sedentary behaviour patterns are not well understood. Methods We investigated cross-sectional associations of neighbourhood walkability with time spent stepping, standing, sitting, and their pattern metrics using data from 505 participants (mean age 59.2 years) from the AusDiab3 study. Neighbourhood walkability (a composite measure of residential, destination, and intersection densities) was calculated within 1 km street-network buffers around participants’ homes. Thigh-worn device data (activPAL, 7-day, 24 h/day protocol) were used to derive stepping, sitting and standing minutes per day and their pattern metrics. Two-level linear mixed models assessed relevant associations, adjusting for potential confounders. Results Higher walkability was associated with higher cadences (β [95% CI] = 0.12 [0.04–0.20]), moderate-to-vigorous physical activity (β [95% CI] = 0.17 [0.09–0.26]), longer stepping bouts (β [95% CI] = 0.18 [0.10–0.25]) and time in purposeful (≥ 2 min duration) walking (β [95% CI] = 0.21 [0.13–0.30]). There were no associations with total sitting time, standing time, or their associated pattern metrics. Total stepping time also had no associations, suggesting that participants in neighbourhoods with higher walkability may accumulate similar levels of stepping time to participants in lower walkability neighbourhoods, albeit with higher intensity and in longer bouts. Conclusions By examining activity totals only, relevant walkability relationships may be masked. Further research is needed to understand whether walkability and other built environment attributes are associated with sedentary behaviour patterns, as well as light-intensity physical activities.
No abstract is provided for this article.
This study aimed to investigate gender, race/ethnicity, education, and income as moderators of relations of perceived neighborhood crime, pedestrian, and traffic safety to physical activity.Participants were from two samples: adults (N = 2199, age = 25-65 yr) and older adults (N = 718, age = 66+ yr) from high- and low-walkable neighborhoods in the Washington, DC, and Seattle, Washington, areas. Neighborhood safety and transportation and leisure walking were assessed via survey, and moderate to vigorous physical activity was assessed using accelerometers. Sociodemographic moderators were investigated using interaction terms and follow-up within-group tests from mixed-effects regression models.Overall direct effects of safety on physical activity were not found, with one exception. Seven interactions were found in each sample. Interactions were found for all physical activity outcomes, although total moderate to vigorous physical activity was involved in more interactions in adults than older adults. Half of the interactions revealed significant positive relations of pedestrian and traffic safety to physical activity in the more affluent/advantaged group (i.e., high education, high income, and non-Hispanic white) and null associations in the less affluent/advantaged group. Race/ethnicity was a moderator only in older adults. One-third of the interactions involved gender; half of these involved crime safety. Interactions involving crime safety showed nonsignificant positive trends in the more affluent/advantaged group and women and nonsignificant negative trends in the less affluent/advantaged group and men.Sociodemographic moderators of neighborhood safety explained some of the variation in adults' and older adults' physical activity. Patterns suggested positive associations between safety and physical activity in participants with more affluent/advantaged sociodemographic characteristics, although some patterns were inconsistent, particularly for gender. More refined conceptualizations and measures of safety are needed to understand if and how these constructs influence physical activity.
Increasing returns of physician surveys. J F Sallis, S P Fortmann, D S Solomon, and J W FarquharCopyRight https://doi.org/10.2105/AJPH.74.9.1043 Published Online: October 07, 2011
Targeting multiple behaviors for change may provide significant health benefits. This study compared interventions targeting physical activity and nutrition (PAN) concurrently versus physical activity (PA) alone. Adolescents (N=138) were randomized to the PAN or PA intervention or control condition (n=46 per group). Primary outcomes were change in PA accelerometer and 3-day dietary recording from baseline to 3-month follow-up. The PAN and PA interventions were efficacious in supporting boys' (p<.001) but not girls' (p=.663) PA relative to the control condition. Dietary change was minimal. Although the findings do not reveal a decrement to PA promotion when a nutrition intervention was added, neither do they reveal any additional benefit. More studies comparing single versus multibehavioral interventions are needed.
Self Determination Theory posits that individuals may be more likely to initiate and maintain behaviors tied to intrinsic (vs. extrinsic) motivations and may provide a useful framework for understanding youth participation in novel sports. Using the Intrinsic Motivation Inventory (IMI) and Patient-Centered Assessment and Counseling for Exercise Plus Nutrition (PACE+) surveys, motivation and physical activity habits were explored in 27 children/adolescents (ages 7-16) enrolled in Parkour, an individual, non-competitive youth sport. Fifteen Parkour participants were also interviewed to gain an understanding of their motivations for participating. Study participants had high median IMI subscale scores related to interest/enjoyment (6.71/7) and perceived choice (6.40/7) compared to the whole scale. Similarly median sub-scale Pros and Self-Efficacy scores for physical activity from the PACE+ were high (4.25/5 and 3.91/5, respectively). The themes of autonomy and enjoyment were consistently reported in the qualitative interviews, expanding on the quantitative results. Other themes included appreciation for camaraderie, creativity, and a drive for improvement. These results provide early evidence that Parkour, and similar lifestyle sports, may be tied more to intrinsic than extrinsic motivations and could have potential for adoption and maintenance by youth with low motivation to engage in physical activity to promote healthy behaviors.
