With the growing complexity of synthetic biological circuits, robust and systematic methods are needed for design and test. Leveraging lessons learned from the semiconductor and design automation industries, synthetic biologists are starting to adopt computer-aided design and verification software with some success. However, due to the great challenges associated with designing synthetic biological circuits, this nascent approach has to address many problems not present in electronic circuits. In this session, three leading synthetic biologists will share how they have developed software tools to help design and verify their synthetic circuits, the unique challenges they face, and their insights into the next generation of tools for synthetic biology.
<p>PDF - 138KB, Total number and total direct cost of all EGRP grants by year.</p>
Systems that provide network traffic anonymity typically focus on wide-area network topologies, and exploit the infeasibility of eavesdropping on all links to prevent attackers from determining communication peers. This approach is inappropriate for high-security wireless local-area networks, since it does not obscure the traffic volume, allowing attackers to identify critical nodes (e.g., a military HQ) and, given the ability of an attacker to obtain a global view of all communications, the relative ease of identifying the source and destination of traffic flows. These weaknesses derive from the fact that, whereas in wide-area networks the sender, the receiver and the adversary are on different physical links, in wireless networks they may share a single broadcast link. Moreover, the adversary can easily find the physical location of the transmitter and thereby identify the entity sending the traffic, not just its network identity. We introduce Wireless Anonymous Routing (war), an approach to achieve anonymity in a broadcast network. We describe a formal threat model for war and compare it to the traditional anonymity approaches. We show that these are inadequate when applied to the broadcast model, and describe new protocols that preserve security with better performance, adequately addressing the requirements of security-critical environments. We provide analytical and some preliminary experimental evidence that our protocols achieve anonymity at a reasonable cost.
Abstract The contribution of genetic polymorphisms to bone mineral density (BMD) and fracture risk in women is a controversial topic. We evaluated the effect of the XbaI and PvuII polymorphisms of the estrogen receptor α to BMD and fracture risk in a meta-analysis, including published data and additional information from investigators. Five thousand eight hundred thirty-four women from 30 study groups were analyzed with fixed and random effects models. The PvuII polymorphism was not associated with BMD at any skeletal site examined and 95% CIs exclude effects over 0.015 g/cm2 for both the femoral neck and the lumbar spine. Conversely, XX homozygotes (women carrying two copies of the gene variant without an XbaI restriction site) consistently had higher BMD than other subjects. The magnitude of the effect was similar in the femoral neck and lumbar spine (0.014 g/cm2 [95% CI, 0.003–0.025] and 0.015 g/cm2 [95% CI, 0.000–0.030], respectively; no between-study heterogeneity for either). Total body BMD was also significantly higher in XX homozygotes (by 0.039 g/cm2 and 0.029 g/cm2 compared with Xx and xx, respectively). Available data on fractures suggested a protective effect for XX (odds ratio [OR], 0.66 [95% CI, 0.47–0.93] among 1591 women), but not PP (OR, 0.93 [95% CI, 0.72–1.18] among 2229 women). In summary, we have found that XX homozygotes may have higher BMD and also a decreased risk of fractures when compared with carriers of the x allele, whereas the PvuII polymorphism is not associated with either BMD or fracture risk.
ABSTRACT It is unknown to what extent leading researchers are currently involved in the leadership of leading research universities as presidents or as executive board members. The academic administrative leader (president or equivalent role) of each of the 146 Carnegie tier 1 USA universities and of any of the top-100 universities per Times Higher Education (THE) 2024 ranking and the members of the executive governing bodies (Board of Trustees, Council, Corporation or similar) for the each of the top-20 universities per THE 2024 ranking were examined for high citation impact in their scientific subfield. Highly-cited was defined as the top-2% of a composite citation indicator (that considers citations, h-index, co-authorship adjusted hm-index and citations to papers as single, first, last authors) in their main scientific subfield based on career-long impact until end-2022 among all scholars focusing in the same subfield and having published ≥5 full papers. Very highly-cited was similarly defined as the top-0.2%. Science was divided into 174 fields per Science-Metrix classification. 38/146 (26%) tier 1 USA university leaders as of end-2023 were highly-cited and 5/146 (3%) were very highly-cited. The respective figures for the top-100 THE 2024 universities globally were 43/100 and 12/100. For the 13 US universities among the top-20 of THE 2024, the probability of their leader being highly-cited was lower (6/13, 46%) than the probability of a randomly chosen active full tenured professor from their faculty being highly-cited (52-77%). Across 444 board members of 14 top-10 THE 2024 universities with data, only 65 (15%) were academics, and 19 (4%) were highly-cited; academics were rare in USA university boards. Board members had predominantly careers in for-profit companies. In conclusion, leading research universities have a dearth of leaders who are high-impact researchers.
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The achievable off-chip bandwidth of digital IC's is a crucial and often limiting factor in the performance of digital systems. In intra-system interfaces where both latency and bandwidth are important, source-synchronous parallel channels have been adopted as the most effective solution. This work investigates receiver and clocking circuit design techniques for increasing the signalling rate and robustness of such channels. One of the main problems arising in the reception of high speed signals is the adverse effects of high frequency noise. To alleviate these effects, a new class of receiver structures that utilize current integration is proposed. The integration of current on a capacitor based on the incoming signal polarity effectively averages the signal over its valid time period, therefore filtering out high frequency noise. An experimental transceiver prototype utilizing current integrating receivers was designed and fabricated in a 0.8 $\mu$m CMOS technology. The prototype achieves a signaling rate of 740 Mbps/pin operating from a 3.3-V supply with a bit error rate of less than 10$\sp{-14}.$ The second major challenge of inter-chip communication is the design of clock generation and synchronization circuits. Delay locked loops are an attractive alternative to VCO-based phase locked loops due to their simpler design, intrinsic stability, and absence of phase error accumulation. One of their main problems however is their limited phase capture range. A dual loop architecture that eliminates this problem is proposed. This architecture employs a core loop to generate finely spaced clock edges, which are then used by a peripheral loop to generate the output clock through phase interpolation. Due to its digital control, the dual loop can offer great flexibility in the implementation of phase acquisition algorithms. A dual DLL prototype was fabricated in a 0.8 $\mu$m CMOS technology. The prototype achieves 80KHz-400MHz operating range, 12-ps rms jitter and 0.4-ps/mV jitter supply sensitivity.
Recent findings from genome-wide association studies have demonstrated their considerable potential for identify-ing genetic determinants of common diseases of public health significance such as cancer, heart disease, and diabetes (1), but they have also highlighted the continued importance of targeted genotyping to replicate genome-wide association findings (2).Approaches to the integration of evidence in human genome epidemiology have evolved rapidly in the last few years.The combination of results from
We thank Satija and colleagues for their thoughtful editorial on our umbrella systematic review.1 2 They interpret the evidence linking type 2 diabetes to multiple cancers as being strong overall,1 but we think that more caution is needed. Prediction intervals are increasingly thought to …
Abstract Many sources document problems that jeopardize the trustworthiness of systematic reviews. This is a major concern given their potential to influence patient care and impact people's lives. Responsibility for producing trustworthy conclusions on the evidence in systematic reviews is borne primarily by authors who need the necessary training and resources to correctly report on the current knowledge base. Peer reviewers and editors are also accountable; they must ensure that systematic reviews are accurate by demonstrating proper methods. To support all these stakeholders, we attempt to distill the sprawling guidance that is currently available in our recent co‐publication about best tools and practices for systematic reviews. We specifically address how to meet methodological conduct standards applicable to key components of systematic reviews. In this complementary invited review, we place these standards in the context of good scholarship principles for systematic review development. Our intention is to reach a broad audience and potentially improve the trustworthiness of evidence syntheses published in the developmental medicine literature and beyond.
