Publications

• Human immunodeficiency virus (HIV) drug resistance has implications for antiretroviral treatment strategies and for containing the HIV pandemic because the development of HIV drug resistance leads to the requirement for antiretroviral drugs that may be less effective, less well-tolerated, and more expensive than those used in first-line regimens. • HIV drug resistance studies are designed to determine which HIV mutations are selected by antiretroviral drugs and, in turn, how these mutations affect antiretroviral drug susceptibility and response to future antiretroviral treatment regimens. • Such studies collectively form a vital knowledge base essential for monitoring global HIV drug resistance trends, interpreting HIV genotypic tests, and updating HIV treatment guidelines. • Although HIV drug resistance data are collected in many studies, such data are often not publicly shared, prompting the need to recommend best practices to encourage and standardize HIV drug resistance data sharing. • In contrast to other viruses, sharing HIV sequences from phylogenetic studies of transmission dynamics requires additional precautions as HIV transmission is criminalized in many countries and regions. • Our recommendations are designed to ensure that the data that contribute to HIV drug resistance knowledge will be available without undue hardship to those publishing HIV drug resistance studies and without risk to people living with HIV.

Specialized image processing accelerators are necessary to deliver the performance and energy efficiency required by important applications in computer vision, computational photography, and augmented reality. But creating, “programming,” and integrating this hardware into a hardware/software system is difficult. We address this problem by extending the image processing language Halide so users can specify which portions of their applications should become hardware accelerators, and then we provide a compiler that uses this code to automatically create the accelerator along with the “glue” code needed for the user’s application to access this hardware. Starting with Halide not only provides a very high-level functional description of the hardware but also allows our compiler to generate a complete software application, which accesses the hardware for acceleration when appropriate. Our system also provides high-level semantics to explore different mappings of applications to a heterogeneous system, including the flexibility of being able to change the throughput rate of the generated hardware. We demonstrate our approach by mapping applications to a commercial Xilinx Zynq system. Using its FPGA with two low-power ARM cores, our design achieves up to 6× higher performance and 38× lower energy compared to the quad-core ARM CPU on an NVIDIA Tegra K1, and 3.5× higher performance with 12× lower energy compared to the K1’s 192-core GPU.

Abstract Background Previous research on the depression scale of the Patient Health Questionnaire (PHQ-9) has found that different latent factor models have maximized empirical measures of goodness-of-fit. The clinical relevance of these differences is unclear. We aimed to investigate whether depression screening accuracy may be improved by employing latent factor model-based scoring rather than sum scores. Methods We used an individual participant data meta-analysis (IPDMA) database compiled to assess the screening accuracy of the PHQ-9. We included studies that used the Structured Clinical Interview for DSM (SCID) as a reference standard and split those into calibration and validation datasets. In the calibration dataset, we estimated unidimensional, two-dimensional (separating cognitive/affective and somatic symptoms of depression), and bi-factor models, and the respective cut-offs to maximize combined sensitivity and specificity. In the validation dataset, we assessed the differences in (combined) sensitivity and specificity between the latent variable approaches and the optimal sum score (⩾10), using bootstrapping to estimate 95% confidence intervals for the differences. Results The calibration dataset included 24 studies (4378 participants, 652 major depression cases); the validation dataset 17 studies (4252 participants, 568 cases). In the validation dataset, optimal cut-offs of the unidimensional, two-dimensional, and bi-factor models had higher sensitivity (by 0.036, 0.050, 0.049 points, respectively) but lower specificity (0.017, 0.026, 0.019, respectively) compared to the sum score cut-off of ⩾10. Conclusions In a comprehensive dataset of diagnostic studies, scoring using complex latent variable models do not improve screening accuracy of the PHQ-9 meaningfully as compared to the simple sum score approach.

This paper presents an energy-efficient 3-stage Pseudo Single-phase family of Flip-flops (PSPFF) targeted for use in a 3GHz microprocessor in a 40nm, 0.9V CMOS technology. With latencies in line with the fast pulsed-latch and an average switching energy comparable to the master-slave flip-flop, PSPFF achieves an energy-delay product (EDP) which is 42% and 24% lower than the pulsed-latch and the master-slave flip-flop respectively. Measurement results confirm an improvement of at least 300MHz in operating frequency when using the PSPFF in place of the master-slave flip-flop.

Treatment with convalescent plasma compared with placebo or standard of care was not significantly associated with a decrease in all-cause mortality or with any benefit for other clinical outcomes. The certainty of the evidence was low to moderate for all-cause mortality and low for other outcomes.