Publications

Advanced blast furnace operation with hot blast flow control valves

Hot blast flow control valves which can control the flow rate of hot blast at each tuyere and their control system have been developed and applied to Keihin No. 1 BF. These technologies contribute to stable and rational operation compared with conventional ones. This presentation describes the technology of hot blast flow control valves and its implications on the control of heat load at the lower part, the removal of scab, and the control of tapping conditions.

[Studies on the mechanism of antitumor activity of 5-FU and its derivatives--relationship between the inhibition of tumor growth and the inhibition of thymidylate synthetase in vivo].

The relationship between the antitumor activity and the inhibition of thymidylate synthase after oral administration of 5-FU, FT-207 or UFT was examined. The inhibition of tumor growth on sarcoma-180 after oral administration of 5-FU (20 mg/kg), FT-207 (120 mg/kg) or UFT (30 mg/kg) was 40%, 50% or 70%, respectively. It was found that the inhibition of thymidylate synthase in sarcoma-180 tumor tissue after single oral administration of 5-FU (20 mg/kg), FT-207 (30 or 120 mg/kg) or UFT (30 mg/kg) were about 45%, 20%, 50% or 65%, respectively, but the activities of other enzymes involved in DNA synthesis were not almost inhibited. Thymidylate synthase was inhibited more severely by oral administration of UFT (30 mg/kg). The activities of other enzymes were not inhibited even by continuous oral administration of these drugs for 6 or 11 days. The extent of inhibition of thymidylate synthase seemed to be parallel to that of inhibition of tumor growth. These results suggest that the inhibition of thymidylate synthase by FdUMP converted from 5-FU, FT-207 or UFT plays a major role in their antitumor actions.

ChemInform Abstract: Decatromicins A and B, New Antibiotics Produced by Actinomadura sp. MK73‐NF4. Part 2. Structure Determination.

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Design, fabrication and testing of a model heating and cooling system for a vacuum vessel

A full-size model of a typical cooling and heating system for a vacuum vessel was manufactured and examined in order to clarify and enhance the efficiency and reliability of the designed system. The model consisted of two parts; one of which had the same structure as the other and was located facing each other to simulate the adiabatic condition of the vacuum-side of a vacuum vessel. Its components were rectangular plates, eletric heater units, cooling pipes inside of which water and air flew as cooling fluid. A lot of kinds of tests and measurements were performed to evaluate efficiency and reliability on the model. The numerical and theoretical analyses on the system were also carried out using the dimensional finite difference technique. The analytical results agreed pretty well with the experimental.

Tetrodecamycin and Dihydrotetrodecamycin, New Antimicrobial Antibiotics against Pasteurella piscicida Produced by Streptomyces nashvillensis MJ885-mF8. II. Structure Determination.

Recent Activities on Tritium Technologies for ITER and Fusion Reactors at JAEA

The design studies of Atmosphere Detirtiation System (ADS) have been carried out in Japan Atomic Energy Agency (JAEA) as a contribution of Japan to ITER. The performance of ADS has also been investigated under accidental conditions such as fire and co-existing of a poison gas for catalyst like SF6. There is no degradation of Detritiation Factor (DF) under co-existing of CO or CO2 up to 20% as a simulated fire condition. However, only 0.1% of SF6 degrades the DF from more than 1000 to 50, following reduction of water by SF4 etc. (decomposition products of SF6) at 773K of catalyst bed.For the tritium processing technologies, our efforts have been focused on the R & D of the tritium recovery system of breeding blanket. In case of ITER Test Blanket Module, a cryogenic molecular sieve bed system was designed and demonstrated. Furthermore, electro-chemical pumping system using a proton conductor is also investigated to design more effective system. The durability of electrolysis cell for Water Detritiation System (WDS) has been investigated and it is expected that the cell can endure more than 3 years’ operation under the ITER WDS design condition.A series of fundamental studies on tritium safety technologies has been carried out as another major activity of JAEA for ITER and future fusion demo reactors. Tritium behavior in various confinement materials, tritium monitoring & accountancy, and detritiation were studied under collaboration programs with universities, using Caisson Assembly for Tritium Safety study.

Simulation of degradation of bond stress and slip relationship with corrosion induced crack

Quantifying the Feedback Between Rice Architecture, Physiology, and Microclimate Under Current and Future CO₂ Conditions

Abstract To assess the micrometeorological consequences of rice variety choices in relation to rising CO 2 associated to climate change, we quantified the interplay between rice architecture, physiology, and microclimate in current (~385 μmol mol −1 ) and future (~580 μmol mol −1 ) CO 2 microenvironments. Two rice varieties contrasting in canopy structure and physiology were grown embedded in irrigated rice paddies, under elevated CO 2 (using a Free‐Air CO 2 Enrichment facility) and ambient CO 2 conditions. The high‐yielding indica variety Takanari is more photosynthetically active and characterized by a more open canopy than a commonly cultivated variety Koshihikari . Our results show a strong diurnal interplay between solar angle, canopy structure, plant physiology, and the overlying atmosphere. Plant architecture was identified as a strong determinant of the relation between plant physiology and microclimate that in turn affects the surface forcing to the overlying atmosphere. Takanari was able to maintain lower canopy temperature both in current and future CO 2 owing to the greater atmospheric mixing and stomatal conductance than Koshihikari. In the perspective of food security, a shift to such a higher‐yielding variety would have consequences on the regional surface energy balance, which subsequently might alter regional weather.

Strengthening of flat slabs with FRP fan for punching shear

ChemInform Abstract: The Synthetic Reactions of Aliphatic Nitro Compounds. Part 25. Formation of 4‐Benzamidoisoxazole Derivatives.

Abstract Reaction of the nitrile oxides (III) (generated in situ from the nitro compounds (I)) with the aziridine (II) yields the title compounds (IV).

DNA Modifications by the ω-3 Lipid Peroxidation-Derived Mutagen 4-Oxo-2-hexenal in Vitro and Their Analysis in Mouse and Human DNA

4-Oxo-2-hexenal (4-OHE), which forms a 2′-deoxyguanosine (dG) adduct in a model lipid peroxidation system, is mutagenic in the Ames test. It is generated by the oxidation of ω-3 fatty acids and is commonly found in dietary fats, such as fish oil, perilla oil, rapeseed oil, and soybean oil. 4-OHE also forms adducts with 2′-deoxyadenosine (dA), 2′-deoxycytidine (dC), and 5-methyl-2′-deoxycytidine (5-Me-dC) in DNA. In this study, we characterized the structures of these adducts in detail. We measured the amounts of 4-OHE−DNA adducts in mouse organs by LC/MS/MS, after 4-OHE was orally administered to mice. The 4-OHE−dA, 4-OHE−dC, 4-OHE−dG, and 4-OHE−5-Me-dC adducts were detected in stomach and intestinal DNA in the range of 0.25−43.71/108 bases. After the 4-OHE administration, the amounts of these DNA adducts decreased gradually over 7 days. We also detected 4-OHE−dC in human lung DNA, in the range of 2.6−5.9/109 bases. No difference in the 4-OHE adduct levels was detected between smokers and nonsmokers. Our results suggest that 4-OHE−DNA adducts are formed by endogenous as well as environmental lipid peroxides.

Evaluation of Coupled Hygro-Mechanical Behavior of Heat-Damaged Mortars During Post-Heating Water Absorption Using DICM

The JT-60 tokamak machine

Altemicidin, a new acaricidal and antitumor substance. II. Structure determination.

Fundamental Study of Crack Propagation of External Sulfate Attack with Mesoscale Analysis System for Coupled Chemo-Mechanical Behaviours

In this study, three dimensional numerical analysis systems, which can consider the change in physico-chemical property and expansive strain due to external sulfate attack, was constructed in order to evaluate the process of expansion cracking behavior.This analysis was coupled with cement hydration model, sulfate attack analysis and Rigid Body Spring Model.In this paper, this analysis was conducted to evaluate the expansive crack propagation in association with cement source and mix proportion.As results, it was confirmed that this analysis can describe signature expansion cracking behavior.

Synthesis of NF-κB activation inhibitors derived from epoxyquinomicin C

Tension Stiffening Analysis of Reinforced Sfrc Using Mesoscale Model Considering the Effects of Cracking and Localized Rebar Yielding

3138 Shear Behavior Analysis of Steel-Tube Concrete Composite Columns