Publications

Potential anti-cancer performance of chitosan-based β-ketosulfone derivatives

A series of chitosan-based β-ketosulfone derivatives (CsB-β-KS) were synthesized, characterized, and evaluated as anti-cancer agents against three types of cancer cell lines, including the colon carcinoma (HCT), liver hepatocellular carcinoma (HEPG2), and breast carcinoma (MCF-7) cell lines. Before product formation, the β-ketosulfone derivatives, 1-(4-halophenyl)-2-(phenylsulfonyl)ethanone, were synthesized by the reaction of phenacyl halide with sodium benzene sulfinate. The (CsB-β-KS)a-e derivatives were synthesized by chemical modification of chitosan (Cs) with freshly prepared p-halo-β-ketosulfone derivatives in a mildly acidic aqueous solution. Various loading percentages, 5%, 10%, 15%, and 20%, of the p-halo-β-ketosulfone derivative (by weight) with respect to the Cs weight were evaluated. The chemical structures were confirmed by variable elemental and spectral analyses, including FT-IR, 1H-NMR, 13C-NMR, and mass spectroscopes. The (CsB-β-KS)a-e derivatives were also characterized by various techniques, such as FT-IR, 1H-NMR, XRD, FE-SEM, and thermal analyses. FT-IR spectroscopy and XRD confirmed the formation of these products. Moreover, the XRD results proved the strong interactions between the organic substituent and the Cs host molecule. All (CsB-β-KS)a-e derivatives showed similar thermal stabilities in three degradation steps. Among these derivatives, (CsB-β-KS)a3 showed the highest thermal stability. The synthesized compounds showed significant biological screening against Gram-positive and Gram-negative bacteria and fungi. Among the tested products, (CsB-β-KS)a3 displayed high efficiencies toward the three types of cancer cell lines under investigation with low concentrations. The ranking of the anti-cancer activity was (CsB-β-KS)a3 > (CsB-β-KS)d3 > (CsB-β-KS)d2.

2-Hydroxy-2-trifluoromethyl-3,4-dihydro-2<i>H</i>-1-benzopyran-4-one

The heterocyclic ring in the title compound, C(10)H(7)F(3)O(3), has a half-boat conformation with the hy-droxy-bearing C atom lying 0.595 (3) Å out of the plane of the five remaining atoms (r.m.s. deviation = 0.022 Å) in the direction of the hy-droxy O atom. Linear supra-molecular chains along the a axis, sustained by O-H⋯O hydrogen bonds between the hy-droxy H and ketone O atoms, feature in the crystal packing. These chains are connected into a three-dimensional architecture by C-H⋯O and C-H⋯F contacts.

UV–visible absorption, fluorescence characteristics and laser activity of (E,E)-2,5-bis(4-methoxystyryl)pyrazine (BMSP)

Isolation and Production of Nanocrystalline Cellulose from Conocarpus Fiber

Conocarpus fiber is a lignocellulosic biomass rich in cellulose potentially used for producing nanocrystalline cellulose (NCC), a biomaterial extensively employed in various application fields. In the present work, different hydrolysis times of 10, 20 and 30 min were applied to chemically pre-treated Conocarpus fiber to produce CPNC1, CPNC2, and CPNC3 particles. With acid hydrolysis treatment, the yield of NCC product was successfully retained at 17-19%. Individual, rod-like shapes of NCC particles could be clearly observed under microscopy examination. From chemical composition analysis, a relatively pure cellulose compartment was produced for all NCC samples with substantial removal of lignin and hemicellulose. The physicochemical analysis proved that each nanoparticle sample possessed strong cellulose crystalline structure. For thermal analyses, the heat resistance of NCCs was gradually enhanced with the increased hydrolysis times. Therefore, the extracted NCC product from Conocarpus fiber could be a green nano-filler for developing nanocomposite material in the future.

Light induced DNA-functionalized TiO2 nanocrystalline interface: Theoretical and experimental insights towards DNA damage detection

Increasing efficiency of perovskite solar cells using low concentrating photovoltaic systems

Perovskite solar cell (PSC) technology is the flag bearer for the future of photovoltaics allowing unlimited possibilities for its application.

A convenient method for conversion of the Z-isomer to the E-isomer from a mixture containing both isomers of fulgides

Shockproof Deformable Infrared Radiation Sensors Based on a Polymeric Rubber and Organic Semiconductor H2Pc-CNT Composite

Polymeric rubber and organic semiconductor H₂Pc-CNT-composite-based surface- and sandwich-type shockproof deformable infrared radiation (IR) sensors were fabricated using a rubbing-in technique. CNT and CNT-H₂Pc (30:70 wt.%) composite layers were deposited on a polymeric rubber substrate as electrodes and active layers, respectively. Under the effect of IR irradiation (0 to 3700 W/m²), the resistance and the impedance of the surface-type sensors decreased up to 1.49 and 1.36 times, respectively. In the same conditions, the resistance and the impedance of the sandwich-type sensors decreased up to 1.46 and 1.35 times, respectively. The temperature coefficients of resistance (<i>TCR</i>) of the surface- and sandwich-type sensors are 1.2 and 1.1, respectively. The novel ratio of the H₂Pc-CNT composite ingredients and comparably high value of the <i>TCR</i> make the devices attractive for bolometric applications meant to measure the intensity of infrared radiation. Moreover, given their easy fabrication and low-cost materials, the fabricated devices have great potential for commercialization.

Recent Development of Chitosan Nanocomposites for Environmental Applications

ChemInform Abstract: Studies on Piezochromic Photochromic (E)‐5‐Dicyanomethylene‐3‐ [1‐(2,5‐dimethyl‐3‐furyl)ethylidene] ‐4‐diphenylmethylenetetrahydrofuran‐2‐one and Related Photochromic Compounds.

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Supplementary material from "Synthesis and characterization of geminis and implications of their micellar solution on ninhydrin and metal amino acid complex"

In our study, three gemini dicationic surfactants with different methylene group spacer (16-6-16, 16-5-16 and 16-4-16) have been synthesized and characterized in solution by ¹H NMR spectroscopic technique. The implications of gemini micellar solution on ninhydrin and metal amino acid complex ([Cu(II)-Trp]⁺) were performed by the means of single-beam UV–visible spectroscopy. The absorbance was noted at regular time intermissions and values of rate constant (<i>k_ψ</i>) were determined by using a computer-based program. Synthesized surfactants proved as an efficient catalyst on the interaction of ninhydrin with metal amino acid complex as compared to conventional surfactant and aqueous systems. The required description regarding the implications of gemini dicationic surfactants are provided in the text in detail. The conductivity technique was applied in order to get critical micelle concentration (cmc) of geminis in the presence and absence of reactants. Catalytic results developed in gemini dicationic surfactant system were explained effectively by pseudo-phase model. Various thermodynamic quantities, <i>viz</i>., activation energy, <i>E</i>_a, activation enthalpy, <i>ΔH</i>^#, and activation entropy, <i>ΔS</i>^#, were obtained on interaction of ninhydrin with [Cu(II)-Trp]⁺in gemini systems by applying Eyring equation. A detailed explanation about these evaluated parameters was also made.

Hierarchically porous N-doped carbon nanoflakes: Large-scale facile synthesis and application as an oxygen reduction reaction electrocatalyst with high activity

Synthesis of some new fluorine substituted thiobarbituric acid derivatives as anti HIV1 and cyclin-dependent kinase 2 (CDK2) for cell tumor division: Part I

New potential enzyme inhibitors, fluorine-substituted thiobarbituric acid derivatives (2, 3, 9, 8 and 12) and their fused/isolated heterocyclic nitrogen systems (5, 6, 10 and 14) have been obtained from heterocyclization of fluorinated N , N ʹ-disubstituted thiourea (1, 7 and 11) with malonic acid followed by ring closure reactions with primary nitrogen reagents. Structures of the synthesized products have been deduced from their elemental analysis and spectral data. Anti-HIV-1 and inhibition of cyclin-dependent kinase2 (CDK2) for cell tumor division for the synthesized compounds were also evaluated.

CCDC 834308: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes

Synthesis and biological evaluation of new 3,5-di(trifluoromethyl)-1,2,4-triazolesulfonylurea and thiourea derivatives as antidiabetic and antimicrobial agents

CCDC 968352: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Synthesis of Mn3O4 nanoparticles via chemical precipitation approach for supercapacitor application