An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Since some types of honey interact synergistically at sub-lethal (sub MIC) concentrations with antibiotics, the work tested this activity of six Egyptian honey brands; three of potent (fennel, 2 of anise & black seed) as well as three of fair antimicrobial activity (multi-floral) against two G-ve and two G+ve multi drug resistant bacterial strains [E. coli AUMC B-243, Klebsiella pneumonia AUMC B-257 and Strept. agalactiae AUMC B-253 and methicillin resistant Staphylococcus aureus (MRSA)] using agar dilution method. The four bacterial strains had high resistance index (RI) ranging (0.18 – 0.73). All tested honey brands had different potencies of antimicrobial activity against all bacterial strains with MICs values (6-15 %), where the best overall MIC was with the use of anise & black seed II (8.5 %) followed by fennel (9.5 %). Either of potent or fair antimicrobial honey brands showed synergistic action with different antimicrobial agents against MRSA with synergistic index (SI) ranged from 0.17 up to 0.39, where the best overall SI of each honey brand against the tested antimicrobial agents was with the use of anise & black seed I (0.39) followed by fennel (0.37). None of the tested honey types showed bactericidal action and all had bacteriostatic activity but the interesting wonderful observation as that all tested Egyptian honey brands (either with of potent or fair activity) restored MRSA (methicillin resistant Staphylococcus aureus) sensitive to Oxacillin being MESSA (methicillin sensitive Staphylococcus aureus). The study concluded that all six tested honey either of potent or fair antimicrobial activity honey brands had variable synergistic activity with antibiotics against MRSA and restored it sensitive to Oxacillin. Keywords: Egyptian honey, antimicrobial, MRSA, synergism
Abstract Review: 78 refs.
Herein we report on the study of the interactions between alkanediyl-α,ω-type cationic dimeric (gemini) surfactant and the nonionic Triton X-100 in aqueous medium. The critical micelle concentrations of binary mixtures were determined by fluorometric study. Using the regular solution theory for the analysis of the experimental data, the attractive nature of interactions and synergistic behavior of gemini surfactant and Triton X-100 mixture were demonstrated. The micelle aggregation number was measured using steady state fluorescence quenching method. The micropolarity, binding constant and dielectric constant of mixed systems were determined from the ratio of peak’s intensity (I 1/I 3) in the pyrene fluorescence emission spectrum.
