2,859 publications from this institution
We investigated the antibacterial activity of some new macromolecules such as bis‐pyrazoline, bis‐pyrazole, bis‐pyrimidines prepared from the reaction of bis‐chalcone with thiosemicarbazide/phenyl hydrazine/guanidine hydrochloride/thiourea. All the macromolecules have been characterized by IR, 1 H NMR, 13 C NMR, mass and elemental analyses. The antibacterial activity of these compounds was first tested in vitro by the disc diffusion assay against two Gram‐positive and two Gram‐negative bacteria, and then the minimum inhibitory concentration was determined with the reference to standard drug chloramphenicol. The results showed that pyrazoline derivative showed better antibacterial activity on S. typhimurium and E. coli than the reference drug chloramphenicol.
INTRODUCTIONCurrent evidence on the incidence and outcomes of patients with thyroid storm in Malaysia is limited. We determined the incidence of thyrotoxicosis with and without thyroid storm and clinical outcomes among hospitalised patients in a tertiary hospital during an 8-year period. METHODOLOGYA retrospective analysis of clinical characteristics, mortality, hospital length of stay and treatment of thyrotoxic patients with age more than 18 years old in a tertiary hospital with an endocrine service from 2000 to 2018 was performed. Electronic medical records were reviewed to obtain data on predisposing factors, associated conditions and treatment during hospitalisation. RESULTSA total of 249 hospitalised patients with thyrotoxicosis were included. Most were female (73.9%), with a mean age 48.23±0.154 years, and of Malay (26.1%), Chinese (13.7%) and Indian (3.2%) ethnicity. Only 19 (7.7%) were diagnosed with thyroid storm. Graves’ disease (59.8%) was the most common cause of hyperthyroidism, and 15.7% of these hospitalised patient were admitted after one month of being diagnosed. Majority of the patients received carbimazole (81%), with a mean dosage of 20.7 mg OD (±0.77). Precipitating factors included a history of non-compliance to anti-thyroid medication (27.7%) and surgical procedure (10.8%). Mortality and mean length of stay for thyrotoxicosis with or without storm is 6% and5.91 days (±0.356), respectively. The associated conditions that may have increased morbidity were found in many patients: these included atrial ffibrillation (18.9%), acute heart failure (11.6%), acute respiratory failure (10%), acute coronary syndrome (8%), acute renal failure (4.8%), invasive ventilation (4.4%), diabetic ketoacidosis (3.6%), acute ischemic stroke (3.2%), cardiac arrest (2%), acute liver failure (1.8%), ssupraventricular tachycardia (1.2%), cardiogenic shock (1.2%), non-invasive positive pressure ventilation (1.2%), encephalopathy (1.2%), intracranial haemorrhage (1.2%), adrenal insufficiency (0.8%) and pulmonary embolism (0.4%). CONCLUSIONAssociated conditions were found to be frequent in hospitalized patient with thyrotoxicosis with or without thyroid storm. The small percentage of thyroid storm may reflect underreporting or under recognition.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Abstract Mixed micellization behavior of an amphiphilic phenothiazine drug promazine hydrochloride (PMZ) in the presence of conventional dodecyltrimethylammonium bromide (DTAB) as well as gemini 1,4-bis( N -dodecyl- N , N -dimethylammonium)butane bromide (12-4-12) cationic surfactants has been studied at four different fixed temperatures and compositions by conductometric technique. The experimental data have been analysed by considering different theoretical models of Clint, Rubingh, Motomura and Rodenas. The cmc and cmc id values indicate mixed micelle formation between the components and strong synergism is observed in the mixed systems. The micellar (actual) mole fractions of surfactants ( χ 1 Rub , χ 1 M , χ 1 Rod and χ 1 id ), calculated on the basis of different theoretical proposed models used in the present study, show greater contribution of surfactants in mixed micelles. Activity coefficients ( f 1 and f 2 ) are always less than unity indicating nonideality in the systems. Thermodynamic parameters are also evaluated and discussed which suggest that at higher temperatures dehydration of hydrophobic part of the drug takes place.
Significant twists between the aromatic rings are evident in the structure of the title compound, C(16)H(12)F(3)N(3)O(2)S. With reference to the pyrazole plane, the N- and C-bound benzene rings form dihedral angles of 57.12 (11) and 29.75 (11)°, respectively. The dihedral angle between the benzene rings is 52.82 (11)°. The presence of N-H⋯O(sulfonamide) and N-H⋯N(pyrazole) hydrogen bonds lead to supra-molecular tubes along the b-axis direction. These are connected into layers via C-H⋯O inter-actions involving a bifurcated O atom (not involved in the N-H⋯O hydrogen bonding). Layers stack along the a-axis direction.
