Vascular Smooth Muscle Cell Peroxisome Proliferator–Activated Receptor-γ Mediates Pioglitazone-Reduced Vascular Lesion Formation

Michael R Hamblin; Lin Chang; Hengmin Zhang; Kun Yang; Jifeng Zhang; Y. Eugene Chen

doi:10.1161/atvbaha.110.219006

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Vascular Smooth Muscle Cell Peroxisome Proliferator–Activated Receptor-γ Mediates Pioglitazone-Reduced Vascular Lesion Formation

Article 2010 en

Abstract

1 min read

Loss of PPARγ in VSMC promotes transplantation-associated vascular lesion formation through increased VCAM-1 expression. VSMC PPARγ also mediates pioglitazone-reduced vascular lesion formation.

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