Unilateral Testicular Enlargement Resulting from Inapparent 21-Hybroxylase Deficiency

No AccessJournal of Urology1 Jul 1981Unilateral Testicular Enlargement Resulting from Inapparent 21-Hybroxylase Deficiency George P. Chrousos, D. Lynn Loriaux, Richard J. Sherins, and Gordon B. Cutler George P. ChrousosGeorge P. Chrousos , D. Lynn LoriauxD. Lynn Loriaux , Richard J. SherinsRichard J. Sherins , and Gordon B. CutlerGordon B. Cutler View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)54411-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail We report a case in which unilateral testicular enlargement was the only presenting sign in 21-hydroxylase deficiency of the "acquired" or adult onset type. Measurement of plasma 17-hydroxyprogesterone throughout 24 hours revealed marked elevations, mostly between 0400 and 0700 hours. However, this steroid increased more than 18-fold 30 minutes following adrenocorticotropic hormone administration, confirming the diagnosis. Glucocorticoid therapy corrected the testicular enlargement. Inapparent 21-hydroxylase deficiency is a medically treatable cause of testicular enlargement that can be diagnosed by measurement of plasma 17-hydroxyprogesterone during a 30-minute adrenocorticotropic hormone stimulation test. © 1981 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByRUBENSTEIN R, DOGRA V, SEFTEL A and RESNICK M (2018) Benign Intrascrotal LesionsJournal of Urology, VOL. 171, NO. 5, (1765-1772), Online publication date: 1-May-2004.Handelsman D, Yue D and Turtle J (2018) Hypogonadism and Massive Testicular Infiltration Due to AmyloidosisJournal of Urology, VOL. 129, NO. 3, (610-612), Online publication date: 1-Mar-1983. Volume 126Issue 1July 1981Page: 127-128 Advertisement Copyright & Permissions© 1981 by The American Urological Association Education and Research, Inc.MetricsAuthor Information George P. Chrousos More articles by this author D. Lynn Loriaux More articles by this author Richard J. Sherins More articles by this author Gordon B. Cutler More articles by this author Expand All Advertisement Loading ...