Late-Onset 21-Hydroxylase Deficiency

Letters and Corrections1 August 1982Late-Onset 21-Hydroxylase DeficiencyGEORGE P. CHROUSOS, M.D., ABRAHAM MUNABI, M.D., GORDON B. CUTLER JR., M.D., D. LYNN LORIAUX, M.D., PH.D.GEORGE P. CHROUSOS, M.D.Search for more papers by this author, ABRAHAM MUNABI, M.D.Search for more papers by this author, GORDON B. CUTLER JR., M.D.Search for more papers by this author, D. LYNN LORIAUX, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-2-281_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Since our article on the diagnosis of late-onset 21-hydroxylase deficiency was published (1), we have been asked the best way to do the 30-minute adrenocorticotrophic hormone (ACTH) stimulation test (1). Most questions center around the intravenous ACTH infusion of 1.67 U over 30 minutes, which is low when compared to the usual dose of 25 U (0.25 mg) given as an intravenous bolus (2), and the mode of administration (continuous versus bolus). The dose of 1.67 U ACTH infused continuously over 30 minutes is a pharmacologic dose that causes maximal adrenal stimulation. Eik-Nes and associates (3) saw...References(1) CHROUSOS G, LORIAUX D, MANN D, and CUTLER G. Late-onset 21-hydroxylase deficiency mimicking idiopathic hirsutism or polycystic ovarian disease: An allelic variant of congenital virilizing adrenal hyperplasia with a milder enzymatic defect. Ann Intern Med. 1982;96:143-8. LinkGoogle Scholar(2) LINDHOLM J, KEHLET H, BLICHERT-TOFT M, DINESEN B, and RIISHEDE J. Reliability of the 30-minute ACTH test in accessing hypothalamic-pituitary-adrenal function. J Clin Endocrinol Metab. 1978;47:272-4. CrossrefMedlineGoogle Scholar(3) EIK-NES K, SANDBERG A, NELSON D, TYLER F, and SAMUELS L. Changes in plasma levels of 17-hydroxycorticosteroids during the intravenous administration of ACTH. I. A test of adrenocortical capacity in the human. J Clin Endocrinol Metab. 1954;33:1502-8. Google Scholar(4) BLANKSTEIN J, FAIMAN C, REYES F, SCHROEDER M, and WINTER J. Adult-onset familial adrenal 21-hydroxylase deficiency. Am J Med. 1980;68:441-8. CrossrefMedlineGoogle Scholar(5) LOBO R and GOEBELSMANN U. Adult manifestation of congenital adrenal hyperplasia due to incomplete 21-hydroxylase deficiency mimicking polycystic ovarian disease. Am J Obstet Gynecol. 1980;138:720-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE P. CHROUSOS, M.D.; ABRAHAM MUNABI, M.D.; GORDON B. CUTLERJR., M.D.; D. LYNN LORIAUX, M.D., PH.D.Affiliations: National Institute of Child Health and Human Development Bethesda, MD 20205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEndocrine profile and phenotype-genotype correlation in unrelated patients with non-classical congenital adrenal hyperplasiaRecovery of the hypothalamic-pituitary-adrenal (HPA) axis in patients with rheumatic diseases receiving low-dose prednisoneLate onset congenital adrenal hyperplasia: a gynecologist’s perspective 1 August 1982Volume 97, Issue 2Page: 281-282KeywordsAdrenocorticotropic hormone ePublished: 1 December 2008 Issue Published: 1 August 1982 PDF downloadLoading ...