tPA enzymatic activity is not necessary in the regulation of aqueous humor outflow. tPA can increase the expression of matrix metalloproteinases in a cytokine-mediated fashion. This cascade of events may eventually lead to extracellular matrix remodeling at the TM, which reverses outflow facility reduction caused by steroids.
Steven Yea, Goutham Narla, Xiao Zhao, Rakhi Garg, Sigal Tal–Kremer, Eldad A. Hod, Augusto Villanueva, Johnny Loke, Mirko Tarocchi, Kunihara Akita, Senji Shirasawa, Takehiko Sasazuki, John A. Martignetti, Josep M. Llovet, Scott L. Friedman
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