The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

(Cell Reports 15, 1481–1492; May 17, 2016) In the originally published version of this article, Michaela Lang, who contributed some of the data shown in Figure 7, was mistakenly omitted from the author list. The corrected version of the article now appears online. The authors regret the error. The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell FateTortola et al.Cell ReportsMay 5, 2016In BriefTortola et al. report that the E3 ubiquitin ligase HACE1 is a gatekeeper of TNFR1-mediated cell fate. Hace1 deficiency impairs TNF-driven NF-κB activation and apoptosis and predisposes cells to necroptosis. Consequently, hace1–/– mice show enhanced colitis and colon cancer, which can be reverted by inactivation of pro-necroptotic kinase RIP3 and TNFR1. Full-Text PDF Open Access