The platelet-derived chemokine CXCL4 mediates experimental liver fibrosis and is associated with HCV and NASH induced fibrosis

Aims: Liver fibrosis is a major cause of morbidity and mortality worldwide. Platelets are involved in liver damage but the underlying molecular mechanisms remain elusive. We here investigate the platelet-derived chemokine CXCL4 as a molecular mediator of fibrotic liver damage.