Deletion of the platelet derived chemokine PF4 (CXCL4) limits liver fibrosis in vivo
Article 2009 de
Authors
MZ
Mirko Moreno Zaldivar
KP
K Pauels
MB
ML Berres
Abstract
1 min read
Aims: Chemokines are inflammatory mediators during acute and chronic liver injury. The chemokine PF4 (CXCL4) is the only chemokine which is mainly secreted by platelets. PF4 has been shown to interact with RANTES (CCL5), thereby increasing monocyte arrest to endothelium. As RANTES has been shown to stimulate hepatic stellate cells and platelets are thought to contribute to liver fibrosis, PF4 might be an interesting novel mediator of liver injury.
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