The microsomal prostaglandin E synthase-1/PGE&lt;sub&gt;2&lt;/sub&gt; /EP4 axis induces blood flow recovery via recruitment of regulatory T cells

Hideki Amano; Kouji Eshima; Yoshiya Ito; Kanako Hosono; Ko Hatanaka; Shuh Narumiya; Akira Shizuo; Masataka Majima

doi:10.1254/jpssuppl.95.0_2-o-100

Abstract

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Microsomal prostaglandin E synthase-1 (mPGES-1)/prostaglandin E2 (PGE2) induces angiogenesis through the prostaglandin E2 receptor (EP1–4). PGE2 is not only known to induce angiogenesis but also known to modulate function and differentiation of regulatory T cells (Tregs). We evaluated effect of Tregs on angiogenesis by using acute hind limb ischemia model.

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Abstract

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Related publications

The microsomal prostaglandin E synthase-1/prostaglandin E2 axis induces recovery from ischaemia via recruitment of regulatory T cells

mPGES-1/PGE<sub>2</sub>/EP4 axis induces blood flow recovery via accumulation of regulatory T cells to ischemic muscle

PGE<sub>2</sub>-EP4 signaling induces blood flow recovery via accumulation of Tregs.

肉芽組織形成を促進するmPGES-1/PGE<sub>2</sub>経路のメカニズムと制御性T細胞との関連性の解析

mPGES-1 promotes granulation tissue angiogenesis through regulatory T-cell accumulation

The microsomal prostaglandin E synthase-1/PGE&lt;sub&gt;2&lt;/sub&gt; /EP4 axis induces blood flow recovery via recruitment of regulatory T cells

Abstract

Discussion(0)

Related publications

The microsomal prostaglandin E synthase-1/prostaglandin E2 axis induces recovery from ischaemia via recruitment of regulatory T cells

mPGES-1/PGE&lt;sub&gt;2&lt;/sub&gt;/EP4 axis induces blood flow recovery via accumulation of regulatory T cells to ischemic muscle

PGE&lt;sub&gt;2&lt;/sub&gt;-EP4 signaling induces blood flow recovery via accumulation of Tregs.

肉芽組織形成を促進するmPGES-1/PGE&lt;sub&gt;2&lt;/sub&gt;経路のメカニズムと制御性T細胞との関連性の解析

mPGES-1 promotes granulation tissue angiogenesis through regulatory T-cell accumulation

The microsomal prostaglandin E synthase-1/PGE<sub>2</sub> /EP4 axis induces blood flow recovery via recruitment of regulatory T cells

mPGES-1/PGE<sub>2</sub>/EP4 axis induces blood flow recovery via accumulation of regulatory T cells to ischemic muscle

PGE<sub>2</sub>-EP4 signaling induces blood flow recovery via accumulation of Tregs.

肉芽組織形成を促進するmPGES-1/PGE<sub>2</sub>経路のメカニズムと制御性T細胞との関連性の解析