肉芽組織形成を促進するmPGES-1/PGE<sub>2</sub>経路のメカニズムと制御性T細胞との関連性の解析

Background)Microsomal prostaglandin (PG) E synthase-1 (mPGEs-1) is the enzyme responsible for the second step of Prostaglandin E2 (PGE2). The expression of mPGEs-1 was observed in various contexts, such as inflammation, fever, pain, female reproduction, and cancer growth. Immune cells, especially regulatory T cells (Tregs) related to cancer growth, tissue repair and angiogenesis. It was reported that PGE2 modulates Tregs cell function and differentiation.Based on these previous reports, we ypothesized mPGEs-1/PGE2 axis contribute to wound healing and granulation formation by accumulation of Tregs.