The itaconate family of immunomodulators grows

Anne F. McGettrick; Luke O'neill

doi:10.1038/s42255-022-00578-w

Article2024

Metabolic Messengers: itaconate

Anne F. McGettrick, L. A. Bourner, Frank C. Dorsey, Luke O'neill

Nature Metabolism

Article2019

Itaconate: the poster child of metabolic reprogramming in macrophage function

Luke O'neill, Maxim N. Artyomov

Nature reviews. Immunology

Article2018

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

Monika Bambousková, Laurent Gorvel, Vicky Lampropoulou, Alexey Sergushichev, Ekaterina Loginicheva, Kendall Johnson, Daniel Korenfeld, Mary Elizabeth Mathyer, Hyeryun Kim, Li-Hao Huang, Dustin Duncan, Howard Bregman, Abdurrahman Keskin, Andrea Santeford, Rajendra S. Apte, Raghav Sehgal, Britney Johnson, Gaya K. Amarasinghe, Miguel P. Soares, Takashi Satoh, Akira Shizuo, Tsonwin Hai, Cristina de Guzman Strong, Karine Auclair, Thomas P. Roddy, Scott A. Biller, Marko Jovanović, Eynav Klechevsky, Kelly M. Stewart, Gwendalyn J. Randolph, Maxim N. Artyomov

Nature

Article2018

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zasłona, Mark P. Jedrychowski, Ana S.H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Román Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L.J. Ashford, Louise K. Modis, Gino Brunori,

Article2024

Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase

Shane M. O’Carroll, Christian G. Peace, Juliana E. Toller-Kawahisa, Yukun Min, Alexander Hooftman, Sara Charki, Louise Kehoe, Maureen J. O’Sullivan, Aline Zoller, Anne F. McGettrick, Emily A. Day, Marı́a Simarro, N. Armstrong, Justin P. Annes, Luke O'neill

Nature Metabolism

The itaconate family of immunomodulators grows

Abstract

Discussion(0)

Related publications

Metabolic Messengers: itaconate

Itaconate: the poster child of metabolic reprogramming in macrophage function

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase