Metabolic Messengers: itaconate

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doi:10.1038/s42255-024-01092-x

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Itaconate: the poster child of metabolic reprogramming in macrophage function

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Nature reviews. Immunology

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The itaconate family of immunomodulators grows

Anne F. McGettrick, Luke O'neill

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Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zasłona, Mark P. Jedrychowski, Ana S.H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin S. King, Joanna F. McGouran, Román Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L.J. Ashford, Louise K. Modis, Gino Brunori,

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Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase

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Nature Metabolism

Metabolic Messengers: itaconate

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Related publications

Itaconate: the poster child of metabolic reprogramming in macrophage function

The itaconate family of immunomodulators grows

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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

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