Synthesis of Imidazo[1,2-a]pyridines as Antiviral Agents

Alain Gueiffier; Sylvie Mavel; Mohammed Lhassani; Ahmed Elhakmaoui; Robert Snoeck; Graciela Andreï; Olivier Chavignon; Jean‐Claude Teulade; Myriam Witvrouw; Jan Balzarini; De Clercq Erik; Jean‐Pierre Chapat

doi:10.1021/jm981051y

Abstract

1 min read

The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.

Related publications

Article1996

Synthesis of Acyclo-C-nucleosides in the Imidazo[1,2-a]pyridine and Pyrimidine Series as Antiviral Agents

Alain Gueiffier, Mohammed Lhassani, Ahmed Elhakmaoui, Robert Snoeck, Graciela Andreï, Olivier Chavignon, Jean‐Claude Teulade, Abdelali Kerbal, El Mokhtar Essassi, Jean‐Claude Debouzy, Myriam Witvrouw, Yves Blache, Jan Balzarini, De Clercq Erik, Jean‐Pierre Chapat

Article2011

Synthesis of Imidazo[1,2-a]pyridine Derivatives as Antiviral Agents

Sylvie Mavel, Jean Louis Renou, Christophe Galtier, Robert Snoeck, Graciela Andreï, Jan Balzarini, De Clercq Erik, Alain Gueiffier

Article2003

Synthesis and Antiviral Activities of 3-Aralkyl-Thiomethylimidazo[1,2-b]Pyridazine Derivatives

Christophe Galtier, Sylvie Mavel, Robert Snoeck, Graciela Andreï, Christophe Pannecouque, Myriam Witvrouw, Jan Balzarini, De Clercq Erik, Alain Gueiffier

Article1996

Synthesis of 2‘-Aminomethyl Derivatives of N-(2-(Phosphonomethoxy)ethyl) Nucleotide Analogues as Potential Antiviral Agents

Hana Dvořáková, Milena Masojı́dková, Antonı́n Holý, Jan Balzarini, Graciela Andreï, Robert Snoeck, De Clercq Erik

Article2001

3-Benzamido, Ureido and Thioureidoimidazo[1,2-a]pyridine Derivatives as Potential Antiviral Agents.

Aziz Chaouni-Benabdallah, Christophe Galtier, H. Allouchi, Abdelak KHERBECHE, Olivier Chavignon, Jean‐Claude Teulade, Myriam Witvrouw, Christophe Pannecouque, Robert Snoeck, Graciela Andreï, Jan Balzarini, De Clercq Erik, Florence Fauvelle, Cécile Enguehard‐Gueiffier, Alain Gueiffier

Synthesis of Imidazo[1,2-<i>a</i>]pyridines as Antiviral Agents

Abstract

Discussion(0)

Related publications

Synthesis of Acyclo-<i>C</i>-nucleosides in the Imidazo[1,2-<i>a</i>]pyridine and Pyrimidine Series as Antiviral Agents

Synthesis of Imidazo[1,2-a]pyridine Derivatives as Antiviral Agents

Synthesis and Antiviral Activities of 3-Aralkyl-Thiomethylimidazo[1,2-<i>b</i>]Pyridazine Derivatives

Synthesis of 2‘-Aminomethyl Derivatives of <i>N</i>-(2-(Phosphonomethoxy)ethyl) Nucleotide Analogues as Potential Antiviral Agents

3-Benzamido, Ureido and Thioureidoimidazo[1,2-a]pyridine Derivatives as Potential Antiviral Agents.