Synthesis of Imidazo[1,2-a]pyridine Derivatives as Antiviral Agents

Sylvie Mavel; Jean Louis Renou; Christophe Galtier; Robert Snoeck; Graciela Andreï; Jan Balzarini; De Clercq Erik; Alain Gueiffier

doi:10.1055/s-0031-1300042

Abstract

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The synthesis and antiviral activity of original dibromoimidazo[1,2-a]pyridines bearing a thioether side chain are reported. Molecular modeling was used to identify biophoric structural patterns that are common to 16 compounds. Structure-activity relationship (SAR) studies identified hydrophobicity (logP) as the most important factor for activity. From these SAR studies, the antiviral activity could be predicted.

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Synthesis of Imidazo[1,2-a]pyridine Derivatives as Antiviral Agents

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