Synthesis and Biological Evaluation of a Series of New Cyclohexenyl Nucleosides

Ping Gu; Jordi Morral; Jing Wang; Jef Rozenski; Roger Busson; Arthur Van Aerschot; De Clercq Erik; Piet Herdewijn

doi:10.1081/ncn-120022668

Abstract

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A series of cyclohexenyl nucleosides (1-8) were successfully prepared with moderate yield and their cytotoxicity and antiviral activity were investigated. Among the eight new compounds, only the diaminopurine analogue 8 showed pronounced activity against HSV-1, HSV-2.

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