Synthesis and antiviral activity of a series of newcyclohexenyl nucleosides

Ping Gu; Jordi Morral-Cardoner; Jing Wang; Jef Rozenski; Roger Busson; Arthur Van Aerschot; De Clercq Erik; Piet Herdewijn

Abstract

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A series of new cyclohexenyl nucleosides is synthesized by coupling the heterocyclic bases with a protected cyclohexenyl precursor under Mitsunobu conditions. The compounds were evaluated for their antiviral and cytostatic activity. Pronounced activity against herpes simplex virus type 1 and type 2 was observed for the 2,6- diaminopurine analogue.

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