Synthesis and Biological Evaluation of 2′,3′-Dideoxy-3′-Fluororibofuranosyl Purine Nucleosides

Nicolai E. Poopeiko; N. B. KHRIPACH; Zygmunt Kazimierczuk; Jan Balzarini; De Clercq Erik; Igor A. Mikhailopulo

doi:10.1080/07328319708006137

Abstract

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Synthesis of 9-(2,3-dideoxy-3-fluoro-beta-D-ribofuranosyl)-2-chloroadenine (7b) and -2-chloro-6-methoxypurine (9b), as well as the alpha-D-anomer 7a of the former and its N-7 isomer 10a is reported. Among the compounds synthesized, only the beta-D-anomer 7b displays moderate cytotoxic activity.

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