Synthesis and Antiviral Evaluation of 3′-Substituted Thymidine Analogues Derived from 3′-Amino-3′-deoxythymidine

Christophe Pannecouque; K. Van Poppel; Jan Balzarini; P. Claes; De Clercq Erik; Piet Herdewijn

doi:10.1080/15257779508012422

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Synthesis and Antiviral Evaluation of 3′-Substituted Thymidine Analogues Derived from 3′-Amino-3′-deoxythymidine

Article 1995 en

Abstract

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Abstract To assess the structure-activity relationship for antiviral activity, a series of 3′-deoxy-3′-N-functionalized thymidine analogues were synthesized. Several of these thymidine analogues show moderate in vitro activity against HIV-1 and HIV-2.

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