3′-(N-Hydroxyimino)-2′,3-dideoxynucleosides and Their Derivatives: Synthesis, Broad Spectrum Antiviral Properties and Synthetical Application for the Preparation of Other Nucleoside Analogues

A series of 3'-(N-hydroxyimino)-2',3'-dideoxynucleosides bearing different nucleic bases has been prepared. In vitro antiviral activity studies showed that among these compounds the thymine derivative possesses significant activity against HIV, HSV, EBV and HBV. Conveniently 5'-protected 3'-(N-hydroxyimino)-2',3'-dideoxythymidine was further used as a synthon for the preparation of other nucleoside analogues.