Synthesis and Antiviral Activities of Some Novel Carbocyclic Nucleosides
Article 1996 en
Authors
MB
María Carmen Balo
FF
Franco Fernández
EL
E. LENS
Abstract
1 min read
Abstract cis-3-Aminomethylcyclopentylmethanol (4), prepared from norbornene (5) in four steps and 51 % overall yield, was used as a precursor in the synthesis of carbocylic nucleosides 13–18 containing guanine and 8-azaguanine bases. None of these compounds had appreciable activity against fourteen viruses in the concentration range tested. Compounds 13 and 16 showed cytotoxicity to all or part of the cell lines used.
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José E. Rodríguez‐Borges, Franco Fernández, Xerardo García‐Mera, Antonio R. Hergueta, Carmen López, Graciela Andreï, Robert Snoeck, Myriam Witvrounw, Jan Balzarini, De Clercq Erik
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