Novel Carbocyclic Nucleosides Containing a Cyclopentyl Ring. Adenosine and Uridine Analogues

Carmen Balo; Franco Fernández; E. LENS; Carmen López; Graciela Andreï; Robert Snoeck; Jan Balzarini; De Clercq Erik

doi:10.1002/ardp.19973300807

Abstract

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cis-3-Aminomethylcyclopentylmethanol (4) was used as a precursor in the synthesis of carbocyclic nucleosides containing adenine, hypoxanthine, 8-azahypoxanthine, uracil, and 5-iodouracil bases. None of these compounds had appreciable activity against eighteen viruses in the concentration ranges tested. Two of them showed a weak cytostatic activity against three tumor lines.

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