SYNTHESIS AND ANTI-HIV ACTIVITY OF NEW MODIFIED 1,2,3-TRIAZOLE ACYCLONUCLEOSIDES

Hassan B. Lazrek; Moha Taourirte; T. Oulih; J. L. Barascut; J.‐L. IMBACH; Christophe Pannecouque; M. Witrouw; De Clercq Erik

doi:10.1081/ncn-100108325

Abstract

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The synthesis of 1,2,3-triazole acyclonucleosides 7a-h via 1,3-dipolar cycloaddition of N-9/N-1-propargylpurine/pyrimidine 2a-h with azido-pseudo-sugar 4 is described and none of them had anti-HIV activity.

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SYNTHESIS AND ANTI-HIV ACTIVITY OF NEW MODIFIED 1,2,3-TRIAZOLE ACYCLONUCLEOSIDES

Abstract

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Related publications

1,2,3-Triazole-[2,5-Bis-O-(tert-butyldimethylsilyl)-.beta.-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) (TSAO) Analogs: Synthesis and Anti-HIV-1 Activity

Regiospecific Synthesis and Anti-Human Immunodeficiency Virus Activity of Novel 5-Substituted <i>N</i>-Alkylcarbamoyl and <i>N,N</i>-Dialkyl Carbamoyl 1,2,3-Triazole-TSAO Analogues

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 4-SUBSTITUTED 1-[1-(2-HYDROXYETHOXY)- METHYL-1,2,3-TRIAZOL-(4 & 5)-YLMETHYL]-1<i>H</i>-PYRAZOLO[3,4-d]PYRIMIDINES

Synthesis and Anti-HIV-1 Activity of 4- and 5-Substituted 1,2,3-Triazole-TSAO Derivatives

Synthesis and anti-HIV activity of various 2'- and 3'-substituted 2',3'-dideoxyadenosines: a structure-activity analysis

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Abstract

Discussion(0)

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