Synthesis and Anti-HIV-1 Activity of 4- and 5-Substituted 1,2,3-Triazole-TSAO Derivatives

Ana San‐Félix; Rosa Álvarez; Sonsoles Veláazquez; De Clercq Erik; Jan Balzarini; Marı́a-José Camarasa

doi:10.1080/15257779508012433

Abstract

1 min read

Abstract Several 4- or 5-monosubstituted and 4,5-disubstituted 1,2,3-triazole analogues of the anti-HIV-1 lead compound [1-[2′,5′-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]thymine]-3′-spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide) (TSAO-T) have been prepared and evaluated for their inhibitory effect against HIV-1-induced cytopathicity.

Related publications

Article1994

1,2,3-Triazole-[2,5-Bis-O-(tert-butyldimethylsilyl)-.beta.-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) (TSAO) Analogs: Synthesis and Anti-HIV-1 Activity

Rosa Álvarez, Sonsoles Velázquez, Ana San‐Félix, Stefano Aquaro, De Clercq Erik, Carlo Federico Perno, Anna Karlsson, Jan Balzarini, Marı́a-José Camarasa

Article1994

Novel Series of TSAO-T Derivatives. Synthesis and Anti-HIV-1 Activity of 4-, 5-, and 6-Substituted Pyrimidine Analogs

Ana San‐Félix, Sonsoles Velázquez, María‐Jesús Pérez‐Pérez, Jan Balzarini, De Clercq Erik, Marı́a-José Camarasa

Article1998

Regiospecific Synthesis and Anti-Human Immunodeficiency Virus Activity of Novel 5-Substituted <i>N</i>-Alkylcarbamoyl and <i>N,N</i>-Dialkyl Carbamoyl 1,2,3-Triazole-TSAO Analogues

Sonsoles Velázquez, Rosa Álvarez, Carlos A. Perez, Federico Gago, De Clercq Erik, Jan Balzarini, Marı́a-José Camarasa

Article2000

TSAO-T Analogues Bearing Amino Acids at Position N-3 of Thymine: Synthesis and Anti-Human Immunodeficiency Virus Activity

Clara Ibel Chamorro, De Clercq Erik, Jan Balzarini, Marı́a-José Camarasa, Ana San‐Félix

Article1993

TSAO analogs. 3. Synthesis and anti-HIV-1 activity of 2',5'-bis-O-(tert-butyldimethylsilyl)-.beta.-D-ribofuranosyl 3'-spiro-5"-(4"-amino-1",2"-oxathiole 2",2"-dioxide) purine and purine-modified nucleosides

Sonsoles Velázquez, Ana San‐Félix, María‐Jesús Pérez‐Pérez, Jan Balzarini, De Clercq Erik, Marı́a-José Camarasa