Release of granzymes and chemokines in Thai patients with leptospirosis
Clinical Microbiology and Infection 13(4): 433-436
Article 2006 English
Authors
MF
Maaike de Fost
WC
Wirongrong Chierakul
RL
R. Limpaiboon
Abstract
1 min read
The plasma concentrations of granzymes are considered to reflect the involvement of cytotoxic T-cells and natural killer cells in various disease states. Interferon (IFN)-γ-inducible protein-10 (IP-10) and monokine induced by IFN-γ (Mig) are members of the non-ELR CXC chemokine family that act on T-cells and natural killer cells. This study revealed that the plasma concentrations of granzyme B (but not granzyme A), IP-10 and Mig were higher in 44 Thai patients with definite or possible leptospirosis than in healthy blood donors. These data suggest that activation of cell-mediated immunity is part of the early host response to leptospirosis.
Fanny N. Lauw, Andrew J. H. Simpson, C. Erik Hack, Jan M. Prins, Angela M. Wolbink, Sander J. H. van Deventer, Wipada Chaowagul, Sir Nicholas White, Tom van der Poll
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