Recent Advances of Aggregation-induced Emission Materials in Phototheranostics

光學診療是一種利用光激活的激發態能量轉化效應實現疾病診斷和同時原位治療的新型診療模式,它具有時空選擇性高、毒副作用低、療效好和可控性強等優點,在疾病診療中展現了巨大的應用潛力。近些年,得益于其生物安全性好、光物理性質可調、易于合成和功能化修飾、出色的熒光和光敏性能、以及可便于構筑多模態診療試劑等優勢,聚集誘導發光材料在光學診療領域取得了重大突破進展。基于此,本文從如何通過精準分子設計以及調控分子在聚集態下的運動構筑高效的聚集誘導發光光診療體系出發,從熒光成像指導的光動力治療、光聲成像指導的光熱治療和多模態成像指導的協同治療三個方面總結了聚集誘導發光材料在光學診療領域的最新研究進展,并對其未來的發展方向與前景進行了展望。 Phototheranostics involving the ingenious integration of light-triggered diagnostics and therapeutics has been recognized to be potentially powerful for disease treatment as it provides high temporal and spatial selectivity, low side effects, high therapeutic effectiveness and controllability. Benefiting from the appreciable biosafety, tuneable photophysical properties, facile processability and functionalization, excellent fluorescence and photosensitizing performances, as well as the feasibility in building multimodal phototheranostic agents, luminogens with aggregation-induced emission(AIE) nature have achieved great breakthrough in the field of phototheranostics over the past few years. This review summarizes the state-of-the-art advancements of AIE luminogens in phototheranostic applications mainly referring to fluorescence imaging-guided photodynamic therapy, photoacoustic imaging-guided photothermal therapy, and multimodal imaging-guided synergistic therapy on the basis of the precise molecular engineering and subtle regulation of molecular aggregation behaviors. Additionally, a brief conclusion and perspectives for the future of this field are also presented at the end of this review. © 2021, Science Press. All right reserved.